Mesenchymal stem cells on osteochondral repair in rats induced to osteoarthritis

• Grant number: 16/13929-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2017
• End date: June 30, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Luis Henrique Montrezor
• Grantee: Gerson Butignoli Junior
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil

Abstract

Osteoarthritis is the most common form of degenerative joint diseases which can affect any joint synovium. Although it is not inevitable as we age, aging is one of the risk factors for the development of osteoarthritis. In addition to age, there are other risk factors for developing the disease: sex, previous joint injury, obesity, genetic predisposition and mechanical factors. It is a disabling disease affecting millions of people around the world, generates important socio-economic burden, and has not yet effective and approved treatment. The use of mesenchymal stem cells to treat various diseases has been an attractive alternative for regenerative medicine. Multipotent cells capable of rapid proliferation and self-renewal capability for differentiation into chondrocytes and that have paracrine anti-inflammatory and immunomodulating effects and wide tissue distribution and modulation of growth factors being used for the treatment of osteoarthritis. The main goal of this study is to analyze the effects of allogenic mesenchymal stem cells on osteochondral repair in castrated rats and uncastrated induced to osteoarthritis of the knee as a result of surgical lesion of the anterior cruciate ligament. (AU)