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Cannabidiol treatment in behaviours related to ethanol addiction: in vitro and in vivo studies

Grant number: 16/18701-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2020
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Fabio Cardoso Cruz
Grantee:Sheila Antonagi Engi
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:13/24986-2 - The role of neuronal ensembles in context-induced reinstatement of ethanol seeking: pharmacogenetic, optogenetic and molecular investigation, AP.JP

Abstract

Drug abuse reached considerable proportions in the last years. Studies have shown that cannabidiol has anxiolytic, anti-psychotic, antidepressant and neuroprotective properties, but less is known about the real mechanism of action of this compound. There are evidences that the treatment with cannabidiol can reduce consumption of other drugs of abuse, such as cocaine and amphetamine. Despite the evidences and the relevance of this study, an extensive literature search did not reveal studies that investigated the effects of the treatment with cannabidiol in behaviors related to ethanol addiction - such as acquisition and relapse of operant self-administration behaviors. In this way, the aim of this project is to investigate whether the treatment with cannabidiol: 1) acts in the mesocorticolimbic system via TRPV1 and/or CB1 receptors, using in vitro techniques; 2) decreases ethanol consumption in the animal model of intermittent access to ethanol; 3) prevents the ethanol relapse using the operant self-administration animal model after exposure to the chamber of ethanol vapor; 4) changes intracellular pathways related to ethanol addiction behaviors. (AU)