Photoacoustic waves and ionizing radiation: laser and X-ray photoacoustic imaging

• Grant number: 16/22720-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: September 08, 2017
• End date: August 17, 2018
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Theo Zeferino Pavan
• Grantee: Diego Ronaldo Thomaz Sampaio
• Supervisor: Richard Robert Bouchard
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: University of Texas MD Anderson Cancer Center (MD Anderson), United States
• Associated to the scholarship: 15/05684-0 - Laser and X-ray induced photoacoustic imaging, BP.DR

Abstract

Photoacoustics is an area of great and still increasing interest. Photoacoustic imaging is now attracting more investigation since it can provide physio-chemical information of tissue non-invasively. In imaging physics, x-ray acoustic imaging is presented as a new tool that have been discussed for radiation detection during external beam radiation therapy (EBRT), providing opportunities to be applied in dosimetry. It is known that multi-wavelength photoacoustic imaging adds molecular information to photoacoustic imaging, obtaining concentrations of endogenous chromophores such as hemoglobin, but more specifically whether it is bound to oxygen or not. In this context, photoacoustic-based images can potentially be employed during cancer treatment, for example, to follow tumor response to EBRT and dosimetry; both of them are important issues for the cancer centers. The main goal of this proposal is to explore the use of multi-wavelength photoacoustic imaging to follow the tumor's response to the EBRT. In addition, generating x-ray acoustic imaging during irradiation for dosimetry. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NASER, MOHAMED A.; SAMPAIO, DIEGO R. T.; MUNOZ, NINA M.; WOOD, CAYLA A.; MITCHAM, TREVOR M.; STEFAN, WOLFGANG; SOKOLOV, KONSTANTIN V.; PAVAN, THEO Z.; AVRITSCHER, RONY; BOUCHARD, RICHARD R.. Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction. IEEE TRANSACTIONS ON MEDICAL IMAGING, v. 38, n. 2, p. 561-571, FEB 2019. (16/22720-3)

SAMPAIO, D.; NASER, M.; MITCHAM, T.; WOOD, C.; PAVONI, J.; PAVAN, T.; BOUCHARD, R.. Removing Noise Bias in Photoacoustic-Based SO2 Estimates: A Simple Empirical SNR-Adaptive Thresholding Approach. Medical Physics, v. 45, n. 6, p. 2-pg., 2018-06-01. (16/22720-3)

WOOD, CAYLA A.; HAN, SANGHEON; KIM, CHANG SOO; WEN, YUNFEI; SAMPAIO, DIEGO R. T.; HARRIS, JUSTIN T.; HOMAN, KIMBERLY A.; SWAIN, JODY L.; EMELIANOV, STANISLAV Y.; SOOD, ANIL K.; et al. Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates. NATURE COMMUNICATIONS, v. 12, n. 1, SEP 13 2021. (16/22720-3)

NASER, MOHAMED A.; MUNOZ, NINA; SAMPAIO, DIEGO R. T.; TAGHAVI, HOURA; MITCHAM, TREVOR; MALDONADO, KIERSTEN; KINGSLEY, CHARLES; AVRITSCHER, RONY; BOUCHARD, RICHARD; DURIC, N; et al. Imaging biomarker development based on microbubble perfusion and oxygen saturation in a rat model of liver cancer. MEDICAL IMAGING 2018: ULTRASONIC IMAGING AND TOMOGRAPHY, v. 10580, p. 10-pg., 2018-01-01. (16/22720-3)