Autonomic heart modulation association with PELD in children liver disease

• Grant number: 16/10570-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2017
• End date: February 29, 2020
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Ana Cristina Aoun Tannuri
• Grantee: Joice Anaize Tonon do Amaral
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 17/25695-2 - Enhancement in heart rate variability and its techniques project of doctor sandwich in the University of Parma - Parma (Italy), BE.EP.DD

Abstract

There are several chronic liver diseases that can manifest itself in childhood. These have a remarkable impact on health care costs, mortality and family dynamics. In some cases there may be progression to cirrhosis and liver failure with all its complications, and may lead to a transplant. There are already studies on the autonomic nervous system in children under different conditions, however, there is in the literature a study to analyze the SNA children with liver disease. Objective: Associate cardiac autonomic modulation with PELD in children chronic liver disease. Method: children will be analyzed diagnosed with severe liver disease undergoing liver transplantation, both sexes, from 6 months to 10 years, who are awaiting transplantation at the Children's Institute, evaluated the PELD as the urgency of the surgery. For HRV data analysis in the time domain will be used (pNN50, SDNN and RMSSD) and the frequency domain will be used spectral components LF low frequency and high frequency HF. The geometric analysis will be performed through RRtri indexes, TINN and Poincaré plot (SD1, SD2, SD1/SD2) and non-linear indices ±1 and ±2. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO AMARAL, JOICE ANAIZE TONON; SALATINI, RENATA; ARAB, CLAUDIA; ABREU, LUIZ CARLOS; VALENTI, VITOR E.; MONTEIRO, CARLOS B. M.; TANNURI, UENIS; TANNURI, ANA CRISTINA AOUN. Non-Alcoholic Cirrhosis and Heart Rate Variability: A Systematic Mini-Review. MEDICINA-LITHUANIA, v. 56, n. 3, MAR 2020. (16/10570-7)

SALATINI, RENATA; AMARAL, JOICE; RAIMUNDO, RODRIGO DAMINELLO; ROCHA, FERNANDO; DE ABREU, LUIZ CARLOS; MORAIS, MAURO; TANNURI, UENIS; TANNURI, ANA CRISTINA. Cardiac autonomic modulation in children with severe liver disease, before and after liver transplantation. TRANSLATIONAL PEDIATRICS, v. 11, n. 4, p. 10-pg., 2021-11-04. (16/10570-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AMARAL, Joice Anaize Tonon do. Association between autonomic modulation of heart rate and the disease severity in children with severe liver disease. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.