Effects of the phytotherapic Polypodium leucotomos on skin cancer: a preliminary investigation on human cell lines

• Grant number: 16/21347-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2017
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Nilva de Karla Cervigne
• Grantee: Mariana Ayaka Yamashita
• Host Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil

Abstract

Skin cancer is a disease with high incidence worldwide. Because Brazil is mostly a tropical country, skin cancer has become one of the most prevalent due to the frequent exposure to the sun's ultraviolet radiation (UVR). Recently, Polypodium leucotomos (PL) extract has been used to treat inflammatory disorders and other skin diseases such as vitiligo and skin damage caused by UVR. PL seens to have photoprotective, antioxidant, and immunomodulating properties. It is speculated that it may, as well, have an antitumor action, since it could protect cellular DNA from damage caused by UVR. In the present study, we access the modulation of the proliferative, the migration and invasion processes of skin cancer cells through the administration of PL extract to determine whether this compound would show any antitumor effect on this cancer cell lines. The results obtained from our study could translate into long-term prevention of photoaging and photocarcinogenesis, and enlighten the administration of P. leucotomos as a potential beneficial tool on skin health, cancer prevention or adjuvant therapy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LACERDA, PAMMELA A.; OENNING, LUAN C.; BELLATO, GUILHERME CUOGHI; LOPES-SANTOS, LUCILENE; ANTUNES, NATALICIA DE JESUS; MARIZ, BRUNO AUGUSTO LINHARES ALMEIDA; TEIXEIRA, GABRIELA; VASCONCELOS, RAFAEL; SIMOES, GUSTAVO FERREIRA; DE SOUZA, IVANI APARECIDA; et al. Polypodium leucotomos targets multiple aspects of oral carcinogenesis and it is a potential antitumor phytotherapy against tongue cancer growth. FRONTIERS IN PHARMACOLOGY, v. 13, p. 18-pg., 2023-01-05. (19/09693-5, 15/10029-1, 18/17495-6, 16/21347-7)