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Grant number: 17/10198-3
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): November 15, 2017
Effective date (End): June 14, 2018
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Clovis Augusto Ribeiro
Grantee:Dânia Elisa Christofoletti Mazzeo Morales
Supervisor abroad: Jorg Oehlmann
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : Goethe University Frankfurt, Germany  
Associated to the scholarship:14/14123-0 - Investigation of the bioremediation potential to detoxify sludge from wastewater treatment plant, regarding estrogenic and dioxin-like compounds, BP.PD


Sewage sludge (SS), a waste generated in Wastewater Treatment Plants (WWTPs), presents a high agronomic potential due to the presence of organic matter, macronutrients, and micronutrients, encouraging its recycling in agriculture as a soil conditioner. However, the presence of toxic substances can preclude this practice. Among these substances, the endocrine disrupting chemicals (EDCs) require special attention since they can cause serious impacts to the environment and associated organisms, even when present in low concentrations. This project aims to verify the biological activity of SS samples regarding the presence of emerging contaminants concerning their estrogenic, anti-estrogenic, androgenic, anti-androgenic and retinoic-like activities. For this, we will combine a fractionation procedure of samples, decreasing the matrix complexity, and in vitro reporter-gene assays performed with recombinant yeasts and human culture cells to detect the presence of EDCs in SS samples, before and after a detoxification treatment. As already predicted in the regular post-doctoral research project, the analyses proposed for this research internship abroad will complement the regular project, increasing the number of assessed effects induced by EDCs. Thus, the performance of the present project will contribute to a valuable monitoring approach to easily detect EDCs in sludges samples, allowing a safe disposal of this waste in agricultural soils.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHRISTOFOLETTI MAZZEO, DANIA ELISA; MISOVIC, ANDREA; OLIVEIRA, FLAVIO ANDRADE; LEVY, CARLOS EMILIO; OEHLMANN, JOERG; RODRIGUES DE MARCHI, MARY ROSA. Effects of biostimulation by sugarcane bagasse and coffee grounds on sewage sludges, focusing agricultural use: Microbial characterization, respirometric assessment and toxicity reduction. WASTE MANAGEMENT, v. 118, p. 110-121, DEC 2020. Web of Science Citations: 0.

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