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Influence of murine IgG repertoire on the maturation of B and gamma-deltaT cells with modulatory and/or regulatory potential in vitro

Grant number: 17/18558-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2017
Effective date (End): October 31, 2018
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Alberto José da Silva Duarte
Grantee:Amanda Harumi Sabô Inoue
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Over the last 15 years our research group has been studying the effects of maternal immunization with allergens. At this time, several mechanisms has been suggested to elucidate the influence of maternal immunization, in this context direct interactions between maternal IgG and offspring lymphocytes during its development in primary lymphoid organs has been highlighted. Preliminary results of our group suggested B and ³dT cells are more susceptible in vivo effects of maternal immunization. Based on these evidences, this project aim to elucidate this mechanism in a in vitro condition. Therefore, purified IgG produced in response to diverse antigens will be used to evaluate its effect upon thymus and bone marrow cells. By means of flow cytometry, we intend to evaluate phenotypic and intracellular cytokine production alterations in different maturation stages of the investigated populations. Using these approaches, we intend to elucidate the potential of IgG exerting a pivotal role upon B and ³dT cells maturation. Taken together, the results obtained from this project can collaborate to the future development of strategies on the immune system regulation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE-OLIVEIRA, MARILIA G.; LIRA, ALINE A. L.; SGNOTTO, FABIO R.; INOUE, AMANDA H. S.; SANTOS, LUDIMILA S.; NAKAMATSU, BERNARDO Y.; DUARTE, ALBERTO J. S.; LEITE-DE-MORAES, MARIA; VICTOR, JEFFERSON R. Maternal IgG impairs the maturation of offspring intrathymic IL-17-producing gamma delta T cells: Implications for murine and human allergies. CLINICAL AND EXPERIMENTAL ALLERGY, v. 49, n. 7, p. 1000-1012, JUL 2019. Web of Science Citations: 2.
DE OLIVEIRA, MARILIA GARCIA; DE LIMA LIRA, ALINE APARECIDA; SGNOTTO, FABIO DA RESSUREICAO; SABO INOUE, AMANDA HARUMI; BELTRAME, GIOVANNA ROSSI; DA SILVA, DEBORA; MENGHINI, RICARDO PALAMAR; DA SILVA DUARTE, ALBERTO JOSE; VICTOR, JEFFERSON RUSSO. Maternal immunization downregulates offspring TCD4 regulatory cells (Tregs) thymic maturation without implications for allergy inhibition. Scandinavian Journal of Immunology, v. 88, n. 6 DEC 2018. Web of Science Citations: 1.
DE LIMA LIRA, ALINE APARECIDA; DE-OLIVEIRA, MARILIA GARCIA; SABO INOUE, AMANDA HARUMI; BELTRAME, GIOVANNA ROSSI; DA SILVA DUARTE, ALBERTO JOSE; VICTOR, JEFFERSON RUSSO. Preconceptional allergen immunization can induce offspring IL-17 secreting B cells (B17): do they share similarities with regulatory B10 cells?. ALLERGOLOGIA ET IMMUNOPATHOLOGIA, v. 46, n. 5, p. 454-459, SEP-OCT 2018. Web of Science Citations: 5.

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