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Analysis of the effects of an enriched environment on metabolism changes caused by newborn stress in Wistar rat

Grant number: 17/18421-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Gláucia Monteiro de Castro
Grantee:Lucas Emanuel Oliveira Carvalho
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

Numerous studies now provide evidence that psychiatric, metabolic, cardiac, and immunologic disorders have their genesis determined by newborn stress. Newborn stress is mediated by the activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis which promotes changes in limbic system structures, especially in the hippocampus, amygdala and prefrontal cortex. Evidences suggest that children are an open field to the different types of environmental stimuli during the perinatal period. Consequently, we hypothesize that deleterious effects from neonatal neglect can be reversed or attenuated by enriched environment stimulus. The enriched environment (EE) is designed to stimulate sensory, motor, cognitive and social interaction activities among animals, generating an improvement in spatial learning, memory and social behaviour. Studies point to an improvement of the neural plasticity associated with EE and linked to increased dendritic branching, the number of synapses per neuron and the number of glial cells. The present project aims to establish the relationship between newborn stress and the effects of exposure to the enriched environment correlating with the changes in metabolic, morphological and stress markers. (AU)