Predictive factors for the development of anemia post-hematopoietic stem cell donations

• Grant number: 17/05694-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2018
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Mauro Kutner
• Grantee: Lia Vineyard Steuer
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

The donation of hematopoietic progenitor cells (HPC), either through bone marrow or apheresis, is a common option for the treatment of onco-hematological diseases. Although it is considered a safe procedure, adverse reactions are expected. Considering the protection of the donors, the global trend is to register the adverse events in a database like the World Marrow Donor Association, Netherlands (WMDA) or the National Marrow Donor Program, Minnesota, USA (NMDP). Their aim is to inform medical professionals about possible adverse events with global implications. Through this data, it was possible to infer that the decrease in hemoglobin values, namely, the development of anemia after HPC donation through bone marrow or apheresis, is a common event. Thus, the objective of this project is to find the predictive factors for the development of anemia post-donation of HPC and, later, possibly, establish criteria for the selection of donors, collection techniques and post-procedure care, looking to improve the outcome for donors. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STEUER, LIA V.; KONDO, ANDREA T.; CIPOLLETTA, ANDREA N.; SAKASHITA, ARACI M.; HAMERSCHLAK, NELSON; KUTNER, JOSE M.. Predictive factors for the development of anemia after hematopoietic stem cell donation. Transfusion, v. 61, n. 1, p. 159-166, JAN 2021. (17/05694-1)