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Evaluation of immunological, inflammatory and biochemical parameters in HIV-infected individuals under antiretroviral therapy in association with propolis

Grant number: 16/24591-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2018
Status:Discontinued
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:José Maurício Sforcin
Grantee:Fernanda Lopes Conte
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

HIV infection represents one of the major public health problems due to its pandemic feature and severity. The therapy combining different antiretroviral drugs (cART) has resulted in increased survival of vírus-infected patients but also led to side effects such as cytotoxicity, metabolic disorders, persistent immune activation and inflammation. The goal of this work is to investigate whether propolis - a natural product with many therapeutic properties - may improve the health of such patients, attenuating the impact of the infection and the side effects of therapy. A standardized extract of propolis developed and standardized by Apis Flora Indl. Coml. Ltda. will be used, showing safety and efficacy. HIV-infected patients under therapy and proper viral suppression will take capsules of propolis for three months. Before and after propolis treatment, the lipid profile (triglycerides, total cholesterol and fractions), concentration of inflammation markers (IL-6, TNF-±, IL-10, PCR and CPK), cytokines related to different T cell profiles (IFN-³, IL-4, IL-17 and TGF-²) and inflammassoma (IL-18, IL-1² and IL-33) in PBMC, phenotyping of T lymphocyte (expression of T-bet, GATA-3, ROR³t and Foxp3) and lymphocyte proliferation will be evaluated. Data may provide bases for propolis use in order to improve the patient quality of life and delay the appearance of comorbidities. (AU)