Evaluation of the activity of ruthenium complexes encapsulated in triple-negative breast tumor metastases

• Grant number: 17/19504-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2018
• End date: August 31, 2019
• Field of knowledge: Biological Sciences - Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Márcia Regina Cominetti
• Grantee: Ramon Handerson Gomes Teles
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated scholarship(s): 18/17170-0 - Importance of the copper transporter 1 receptor in the uptake of the copper complex [Cu(sdmx)2(phen)] into triple negative breast tumor cells, BE.EP.MS

Abstract

Cancer is the second leading cause of death in the world, with breast cancer being the most frequent in women, with impacts in several areas; from the economic impact to the public coffers until the biopsychosocial impact for the patient with the presence of strong side effects during the treatment. Cisplatin is considered one of the best drugs in the treatment of cancer in the world, but it has several side effects. Research on the substitution of platinum by another metallic center, such as ruthenium, shows advantages such as mimicking the action of iron in connection with biomolecules, making the compounds with ruthenium less toxic, compared to platinum. Thus, this project aims to evaluate the action of nanoparticles of ruthenium complexes against triple-negative mouse and human breast cancer cells in vitro and in vivo assays. First, in vitro assays will be carried out for the acquisition of dosimetric and cytotoxic parameters of the nanoparticles of ruthenium complexes and later applied in a model of tumor induction and spontaneous formation of metastases in vivo by injecting tumor cells into the mammary glands of mice. After the experiment period, the organs and the primary tumor will be collected for biochemical and histological analyses. Nanoparticles are expected to show an improvement in the antitumor activity of ruthenium complexes, since the properties of the nanoscale facilitate aspects of the interaction of the drug with the tumor cell, making them more selective, with greater activity and with fewer toxic effects for cells non-tumor cells. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, JOAO MANOEL; GOMES TELES, RAMON HANDERSON; GOMES GATTO, CAMILA DO VALLE; MUNOZ, VITOR ROSETTO; COMINETTI, MARCIA REGINA; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA. Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis. CELLS, v. 8, n. 12, DEC 2019. (17/19504-0, 17/09602-4)

GOMES TELES, RAMON HANDERSON; MORALLES, HERICK FERNANDO; COMINETTI, MARCIA REGINA. Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, p. 2321-2336, 2018. (17/19504-0)

GOMES TELES, RAMON HANDERSON; GRAMINHA, ANGELICA ELLEN; RIVERA-CRUZ, COSETTE M.; NAKAHATA, DOUGLAS HIDEKI; BARBOZA FORMIGA, ANDRE LUIZ; CORBI, PEDRO PAULO; FIGUEIREDO, MARXA LEAO; COMINETTI, MARCIA REGINA. Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment. TOXICOLOGY IN VITRO, v. 67, SEP 2020. (18/12062-4, 15/20882-3, 18/17170-0, 13/07600-3, 17/19504-0)