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Qualitative and quantitative analysis of gingival sulcus cytokines in teeth chosen for metal ceramic crowns during different steps of clinical procedures, in patients taking Angiotensin II AT1a receptor antagonists

Grant number: 17/17747-2
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2018
Effective date (End): June 30, 2019
Field of knowledge:Health Sciences - Dentistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Carlos Ferreira dos Santos
Grantee:Isadora Prado Cano
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated research grant:15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach, AP.TEM


The aim of any restorative procedure is to reestablish or maintain function, esthetics, phonetics and periodontal tissue's health. In dental fixed prosthesis, caries are still the main reason for biological failure, corresponding approximately to 32% of the cases, while periodontal disease takes 4% of the causes, the same for endodontic. The present study looks forward to state if patients in oral rehabilitation using antagonists of receptor AT1 for angiotensin II drugs, and if materials used through treatment for metalo ceramic crowns' confection could change qualitative and quantitatively the cytokines associated to gingival inflammation and bone metabolism in gingival sulcus. The sample will take 20 patients in need of premolar restorations with metalo ceramic crowns. Two groups will be divided (n=10): for test, patients will be taking anti-hypertensive drugs (angiotensin II receptor antagonists, such as losartan and telmisartan) and, the other group: control, patients with no use of these drugs. The parameters analyzed will be the quantitative and qualitative measures for gingival sulcus' cytokines in different steps such as - 1) after crown scaling, 2) 15 days after temporary crowns' installation, 3) 15 days and 4) 6 months after metalo ceramic crowns' cementation. It will also be noticed: pocket depth, clinical attachment loss, gingival recession, gingival index, plaque index and width of attached gingiva. Doses of the used mediators will be registered through mediums and standard deviation and normalized data will be verified with Kolmogorov-Smirnov method. All these analysis will be taken in contralateral premolars taken as positive control. For mean-time comparison in quantitative variance, paired "t" test will be used; for score variances measures, Wilcoxon signed-rank test will be taken. In all statistic tests, the 5% significance level will be taken (p<0,05 will indicate values as significant values). (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANO, ISADORA PRADO; DIONISIO, THIAGO JOSE; CESTARI, TANIA MARY; CALVO, ADRIANA MARIA; COLOMBINI-ISHIKIRIAMA, BELLA LUNA; CARDOSO FARIA, FLAVIO AUGUSTO; SIQUEIRA, WALTER LUIZ; SANTOS, CARLOS FERREIRA. Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. PLoS One, v. 14, n. 5 MAY 22 2019. Web of Science Citations: 0.

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