Polymers inspired by phospholipids: polyesters with dihydrogen phosphate pendent group

• Grant number: 18/01562-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: April 01, 2018
• End date: September 21, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Maria Isabel Felisberti
• Grantee: Giovanni Bortoloni Perin
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM
• Associated scholarship(s): 22/01139-1 - Construction of biomimetic protocells based on polyester nanoparticles and enzymeloaded polymersomes, BE.EP.DD

Abstract

This project aims the synthesis and characterization of amphiphilic polyesters inspired by the structure and self-assembly of phospholipids molecules. These polyesters based on renewable raw-materials and presenting dihydrogen phosphate pendent groups will be synthesized by polycondensation of glycerol monophosphate and dicarboxylics acids with different numbers of methylene groups (sebacic acid, dodecanedioic acid and hexadecanedioic acid). Different catalyst, such as organometallics, enzymatics and inorganic acids, will be used and the polymers structure and properties will be correlated with the polycondensation conditions. The characterization of these polymers will be performed in relation with their composition, structure, morphology and degradation (hydrolytic and enzymatic), besides their thermal and mechanical properties will be also evaluated. Due the specificity of the designed architecture of these polymers inspired by phospholipids, which present long methylene segment of the dicarboxylic acids, the ability of self-assembly is expected. Therefore, the study of the self-assembly in solid and in solution will be studied. These polymers can find applications as materials for biomedical application, flame-retardant materials, electrolytic membranes and materials to complex with metal ions, for instance. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PERIN, GIOVANNI B.; FELISBERTI, MARIA, I. Enzymatic Synthesis of Poly(glycerol sebacate): Kinetics, Chain Growth, and Branching Behavior. MACROMOLECULES, v. 53, n. 18, p. 11-pg., 2020-09-22. (18/01562-6, 15/25406-5)

PERIN, GIOVANNI BORTOLONI; FELISBERTI, MARIA ISABEL. Mechanism and Kinetics of Lipase-Catalyzed Polycondensation of Glycerol and Sebacic Acid: Influence of Solvent and Temperature. Biomacromolecules, v. N/A, p. 8-pg., 2022-06-09. (15/25406-5, 18/01562-6)

BARBOSA, JACQUELINE L.; PERIN, GIOVANNI B.; FELISBERTI, MARIA ISABEL. Plasticization of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with an Oligomeric Polyester: Miscibility and Effect of the Microstructure and Plasticizer Distribution on Thermal and Mechanical Properties. ACS OMEGA, v. 6, n. 4, p. 3278-3290, FEB 2 2021. (18/19091-0, 15/25406-5, 18/01562-6)

PERIN, GIOVANNI B.; FELISBERTI, MARIA I.. Phosphorylated Polyesters Inspired by Phospholipids: Synthesis, Characterization, and Potential Applications. Biomacromolecules, v. N/A, p. 12-pg., 2023-10-04. (18/01562-6, 21/12071-6, 15/25406-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PERIN, Giovanni Bortoloni. Polymers inspired by phospholipids: polyesters with dihydrogen phosphate pendant group. 2023. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.