Preparation and characterization of nanostructured lipid organogels as skin-drug delivery systems

• Grant number: 18/02482-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2018
• End date: April 30, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Daniele Ribeiro de Araujo
• Grantee: Naially Cardoso de Faria
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• Associated research grant: 14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM

Abstract

Although the use of new molecules is an effective strategy for the treatment of different skin pathologies, limitations related to their physicochemical and pharmacological properties have directed researches for the development of new nanocarrier systems and pharmaceutical formulations. Among these systems, there are that formed by the poloxamers (PL) copolymers in combination with oily phases (such as lecithin, oleic acid, etc.) forming organogels, which have the ability to modulate the release and permeation of drugs through of the skin, according to adjustments in their composition. Sulforaphane (SFN) is a phytochemical, a member of the isothiocyanate family, found in cruciferous vegetables such as broccoli and cauliflower. Studies have shown its pharmacological properties as antioxidants, immunomodulatory and anti-inflammatory due to inhibition of lipopolysaccharide production, protection against UV rays and reduction of expression of the cyclooxygenase-2 promoter gene. Thus, this proposal aims from the preparation and physical-chemical characterization to in vitro studies (stability, release, permeation, cytotoxicity) of organogels, containing sulforaphane as drug model, designed to promote the drug permeation through the skin, aiming at the treatment of pathologies such as atopic dermatitis and psoriasis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIGATO, ARYANE ALVES; QUEROBINO, SAMYR MACHADO; DE FARIA, NAIALLY CARDOSO; BOLELA BOVO CANDIDO, ANA CAROLINA; MAGALHAES, LIZANDRA GUIDI; SAIA CEREDA, CINTIA MARIA; TOFOLI, GIOVANA RADOMILLE; RAMOS CAMPOS, ESTEFANIA VANGELIE; MACHADO, IAN POMPERMAYER; FRACETO, LEONARDO FERNANDES; et al. Physico-Chemical Characterization and Biopharmaceutical Evaluation of Lipid-Poloxamer-Based Organogels for Curcumin Skin Delivery. FRONTIERS IN PHARMACOLOGY, v. 10, SEP 12 2019. (18/04036-3, 16/24456-1, 16/18045-9, 18/02482-6, 14/14457-5)

VIGATO, ARYANE ALVES; QUEROBINO, SAMYR MACHADO; DE FARIA, NAIALLY CARDOSO; PINHEIRO DE FREITAS, ANDREA CAROLINA; LEONARDI, GISLAINE RICCI; DE PAULA, ENEIDA; SAIA CEREDA, CINTIA MARIA; TOFOLI, GIOVANA RADOMILLE; DE ARAUJO, DANIELE RIBEIRO. Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. European Journal of Pharmaceutical Sciences, v. 128, p. 270-278, FEB 1 2019. (18/02482-6, 14/14457-5, 18/04036-3)