Ecocardiographic evaluation of rabbits sibmitted to continuous infusion of lidocaine sedated with midazolam

• Grant number: 17/20513-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2018
• End date: February 28, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Paulo Sergio Patto dos Santos
• Grantee: Ana Elisa Gregui Watanabe Marques
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

This study aimed to evaluate the systolic and diastolic functions of the left ventricle of rabbits submitted to continuous infusion of lidocaine. Ten rabbits, male and female, New Zealand weighing approximately 3.5 kg will be used. All animals (n = 10) will undergo two treatments: G1 - midazolam (1 mg / kg /IM) + 0.9% NaCl solution infusion; G2 - midazolam (1 mg/kg/IM) + lidocaine infusion (50 mcg/kg/minute), with a minimum interval of seven days between treatments. The variables heart rate, systolic, diastolic and mean arterial pressure, shortening fraction, ejection fraction, Doppler cardiac index, E / A ratio, E '/ A' and TRIV, will be collected 30 minutes after midazolam (M0) and 20, 40 and 60 minutes (M20, M40 and M60, respectively) after started continuous rate infusion of lidocaine or NaCl 0,9% according to each group. Two-way ANOVA will be used with repeated measures for comparison between moments and groups, followed by multiple comparison tests. The Dunnett test will be used to compare each of the moments with the baseline and the Bonferroni-corrected T-paired test to compare the groups. The differences will be considered significant when the value of P <0.05. If the ANOVA assumptions are not met, the Friedman non-parametric test will be used to compare the moments followed by the Dunn multiple-comparison test and the Wilcoxon test for comparison of the groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARQUES, A. E. G. W.; MARQUES, M. G.; SILVEIRA, B. C. R.; OLIVEIRA, S. P.; FERRAZ, I. G.; VENTRICCI, A. B. G.; SILVA, N. C.; NAGATA, W. B.; FLORIANO, B. P.; FERREIRA, W. L.; et al. Lidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam. VETERINARY AND ANIMAL SCIENCE, v. 10, DEC 2020. (17/20513-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARQUES, Ana Elisa Gregui Watanabe. Echocardiographic evaluation of rabbits submitted to continuous infusion of lidocaine sedated with midazolam. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.