"Encapsulation and surface modulation with polycaprolactone (PCL): seeking a dermal drug-delivery modification"

• Grant number: 18/05421-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: August 01, 2018
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Louise Lacalendola Tundisi
• Supervisor: Daniel Kohane
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Harvard University, Boston, United States
• Associated to the scholarship: 17/10728-2 - Encapsulation and surface modulation with polycaprolactone (PCL): a novel approach for the treatment of topical fungal infections, BP.DR

Abstract

Topical route brings many advantages over oral treatment, since there is no first-pass effect, no drug interactions and usually does not require laboratory monitoring during treatment. On the other hand, it still brings patients some difficulties related mainly to patient compliance once the treatment is long, inconvenient and demanding, which can lead to failure in the treatment. As an improvement in topical drug delivery effectiveness, the investigation of new pharmaceutical formulation is mandatory for increasing patient compliance, by easing the therapeutic regime. In this context, the aim of this proposal is to investigate the modulation of polymeric nanoparticles to modify its release, helping the improvement of patient compliance by manly reducing drug administration times. Modified drug release by polymer systems increases drug efficacy and may lead to decreased dosage and number of daily administrations, maximizing patient compliance and treatment success. Modified release can be controlled by different mechanisms such as: modulation of the particle surface, modification in the polymeric design and use of a stimulus-responsive polymer already established. These mechanisms will be studied to choose the one that suits better topical modify drug release, starting with polymer design modification in order to make a redox responsive biopolymer.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TUNDISI, LOUISE LACALENDOLA; YANG, RONG; BORELLI, LUIZ PHELLIPE POZZUTO; ALVES, THAIS; MEHTA, MANISHA; CHAUD, MARCO VINICIUS; MAZZOLA, PRISCILA GAVA; KOHANE, DANIEL S.. Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. PHARMACEUTICAL RESEARCH, v. 38, n. 3, p. 515-522, MAR 2021. (17/10728-2, 18/05421-8, 18/07707-6)

TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; DA FONSECA, JESSICA HELINE LOPES; SILVERIO, LUIZA APARECIDA LUNA; LANCELLOTTI, MARCELO; PAIVA-SANTOS, ANA CLAUDIA; D'AVILA, MARCOS AKIRA; KOHANE, DANIEL S.; MAZZOLA, PRISCILA GAVA. Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. PHARMACEUTICS, v. 15, n. 3, p. 16-pg., 2023-03-01. (18/06475-4, 17/10728-2, 18/07707-6, 18/05421-8)