New transformations involving isoxazol-5-ones

• Grant number: 17/22164-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2018
• End date: April 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Igor Dias Jurberg
• Grantee: Alessandra Aparecida de Godoy Fernandes
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The main objective of this project is to study new reactions involving isoxazol-5-ones as key building blocks. More specifically, metal- and organocatalyzed reactions will be investigated with the objective of preparing a series of important organic molecules, such as pyridines, ketones and isoxazoles. In addition, the chemistry of benzyne will be investigated using isoxazolones as precursors. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES, ALESSANDRA A. G.; STIVANIN, MATEUS L.; JURBERG, IGOR D.. RuCl3/PPh3 - Catalyzed Direct Conversion of Isoxazol-5-ones to 2,3-Disubstituted Pyridines. CHEMISTRYSELECT, v. 4, n. 12, p. 3360-3365, MAR 29 2019. (17/24017-0, 17/22164-6)

THUROW, SAMUEL; FERNANDES, ALESSANDRA A. G.; QUEVEDO-ACOSTA, YOVANNY; DE OLIVEIRA, MATHEUS F.; DE OLIVEIRA, MARCELO G.; JURBERG, IGOR D.. Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)(3)center dot 9H(2)O. ORGANIC LETTERS, v. 21, n. 17, p. 6909-6913, SEP 6 2019. (17/24017-0, 17/22164-6, 18/02520-5, 16/02414-5)

FERNANDES, ALESSANDRA A. G.; DA SILVA, AMANDA F.; OKADA, JR., CELSO Y.; SUZUKAWA, VITOR; CORMANICH, RODRIGO A.; JURBERG, IGOR D.. General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2019, n. 19, p. 3022-3034, MAY 26 2019. (17/22164-6, 17/24017-0, 18/03910-1)

STIVANIN, MATEUS L.; FERNANDES, ALESSANDRA A. G.; DA SILVA, AMANDA F.; OKADA JR, CELSO Y.; JURBERG, IGOR D.. Blue Light-Promoted N-H Insertion of Carbazoles, Pyrazoles and 1,2,3-Triazoles into Aryldiazoacetates. ADVANCED SYNTHESIS & CATALYSIS, v. 362, n. 5, JAN 2020. (17/24017-0, 17/22164-6)

BERLINCK, ROBERTO G. S.; BERNARDI, I, DARLON; FILL, TAICIA; FERNANDES, ALESSANDRA A. G.; JURBERG, IGOR D.. The chemistry and biology of guanidine secondary metabolites. NATURAL PRODUCT REPORTS, v. 38, n. 3, p. 586-667, MAR 1 2021. (13/50228-8, 19/06359-7, 19/01235-8, 16/21341-9, 17/22164-6)

ALESSANDRA A. G. FERNANDES; IGOR D. JURBERG. SYNERGISMS BETWEEN METAL AND PHOTOREDOX CATALYSIS: DECONVOLUTING COMPLEX SYSTEMS. Química Nova, v. 43, n. 7, p. 928-950, 2020-08-21. (17/22164-6, 17/24017-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERNANDES, Alessandra Aparecida de Godoy. New transformations involving isoxazol-5-ones and aryldiazoacetates. 2023. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.