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| Author(s): |
Alessandra Aparecida de Godoy Fernandes
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Instituto de Química |
| Defense date: | 2023-03-31 |
| Examining board members: |
Igor Dias Jurberg;
Alessandro Rodrigues;
Giuliano Cesar Clososki;
Paulo Cesar Muniz de Lacerda Miranda;
Fernando Antonio Santos Coelho
|
| Advisor: | Igor Dias Jurberg |
| Abstract | |
Chapters 1 and 2 of the thesis refer to new transformations involving isoxazol-5-ones. The first contemplates the formation of 2,3-disubstituted pyridines through a single-step decarboxylative cyclization process from isoxazol-5-ones and acrolein using RuCl3/PPh3 as a catalytic system. The second chapter describes the production of 3,5-disubstituted isoxazoles from isoxazol-5-ones. The first step involves the preparation of 5-(pseudo)halogenated isoxazoles, which are then subjected to palladium-catalyzed nucleophilic substitution and cross-coupling reactions. Chapters 3 and 4 involve transformations employing aryldiazoacetates. In chapter 3 was possible to develop a protocol for N-H insertion of nitrogenous heterocycles in aryldiazoacetates using blue light. In chapter 4, Fe(NO3)3.9H2O was used for the nitration of aryldiazoacetates. Most products were obtained in yields above 90% (AU) | |
| FAPESP's process: | 17/22164-6 - New transformations involving isoxazol-5-ones |
| Grantee: | Alessandra Aparecida de Godoy Fernandes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |