Cumulative effects of cognitive frailty, stress and burden on risk for mortality, hospitalizations, falls, and functional decline in older caregivers: four-year follow-up

• Grant number: 18/00265-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2018
• End date: February 28, 2019
• Field of knowledge: Health Sciences - Nursing - Public Health Nursing
• Principal Investigator: Sofia Cristina Iost Pavarini
• Grantee: Allan Gustavo Bregola
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The simultaneous occurrence of cognitive decline and physical frailty, defined as cognitive frailty, is indicated as a risk factor for adverse health outcomes, such as occurrence of hospitalizations, decline in functionality and death. At the same time, care stress and burden have been shown as risk factors for such outcomes in caregivers. There is no evidence that conditions, cognitive fragility and stress /burden, have additive effects on outcomes. Thus, the purpose of this study is to analyze the cumulative effects of the cognitive frailty and the stress/burden of older caregiver on outcomes in a four-year follow-up. This research project was proposed due the first data collection (baseline) carried out in 2014 under the Family Health Program of São Carlos, located in the central-western region of the interior of the State of São Paulo. The study comprised the broad geriatric-gerontological evaluation of 702 participants, including 351 caregivers and their 351 elderly care recipients (non-caregivers). At baseline, global cognitive function and specific cognitive functions (ACE-R battery), physical frailty (five criteria of the Fried's phenotype) and the psychological and emotional well-being related to care (Perceived Stress Scale, Zarit Burden Interview) were assessed variables. In addition, the overall health status and the context of care were measured. Cognitive frailty was defined as the concomitant presence of cognitive decline and physical frailty in participants assessed at baseline. Data on the outcomes will be collected in the year 2018 and comprise home visits for the collection of death information, causes and date and occurrence of hospitalizations and falls in the last year for surviving participants, as well the functional assessment by combined Katz Index and Scale of Lawton and Brody. Transversal and longitudinal analyzes will be conducted using logistic regressions for associations between cognitive frailty and stress /burden and the occurrence of hospitalization, falls and functional decline after four years. Death rates will be calculated and Cox regression models will be constructed to test the cumulative effects of baseline variables as risk factors for all-cause mortality.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALLAN GUSTAVO BREGOLA; ANA CAROLINA OTTAVIANI; BRUNA MORETTI LUCHESI; SOFIA CRISTINA IOST PAVARINI. Demographics and stress as risk factors associated with mortality in older adults who provide daily support and who receive daily support. Jornal Brasileiro de Psiquiatria, n. ahead, p. -, 2021. (17/04129-9, 13/26798-9, 18/00265-8)

ALLAN GUSTAVO BRIGOLA; MAYARA CAROLINE BARBIERI; BRUNA MORETTI LUCHESI; ELIANE DA SILVA GRAZZIANO; REGIMAR CARLA MACHADO; GISELLE DUPAS; SOFIA CRISTINA IOST PAVARINI. Associação entre síndrome depressiva e queixas visuais em idosos cuidadores. Jornal Brasileiro de Psiquiatria, v. 67, n. 4, p. 223-230, 2018-12-00. (13/26798-9, 18/00265-8, 17/04129-9)

ALLAN GUSTAVO BRIGOLA; ANA CAROLINA OTTAVIANI; DANILO HENRIQUE TREVISAN CARVALHO; NATHALIA ALVES OLIVEIRA; ÉRICA NESTOR SOUZA; SOFIA CRISTINA IOST PAVARINI. Associação entre o comprometimento cognitivo e os critérios para a síndrome de fragilidade em idosos. Arquivos de Neuro-Psiquiatria, v. 78, n. 1, p. 2-8, 2020-01-31. (13/26798-9, 18/00265-8)

BRIGOLA, ALLAN GUSTAVO; OTTAVIANI, ANA CAROLINA; ALEXANDRE, TIAGO DA SILVA; LUCHESI, BRUNA MORETTI; IOST PAVARINI, SOFIA CRISTINA. Cumulative effects of cognitive impairment and frailty on functional decline, falls and hospitalization: A four-year follow-up study with older adults. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 87, MAR-APR 2020. (13/26798-9, 18/00265-8, 17/04129-9)

ALLAN GUSTAVO BREGOLA; ANA CAROLINA OTTAVIANI; BRUNA MORETTI LUCHESI; SOFIA CRISTINA IOST PAVARINI. COMBINAÇÃO DE COMPROMETIMENTO COGNITIVO, FRAGILIDADE, SOBRECARGA, ESTRESSE PERCEBIDO E O RISCO DE HOSPITALIZAÇÃO E MORTALIDADE EM IDOSOS CUIDADORES. Dement. Neuropsychol., v. 16, n. 1, p. 33-44, 2022-04-11. (13/26798-9, 18/00265-8, 17/04129-9)

ALLAN GUSTAVO BREGOLA; ANA CAROLINA OTTAVIANI; BRUNA MORETTI LUCHESI; SOFIA CRISTINA IOST PAVARINI. Dados demográficos e estresse como fatores de risco associados à mortalidade de idosos cuidadores e idosos receptores de cuidado. Jornal Brasileiro de Psiquiatria, v. 70, n. 3, p. 253-260, 2021-05-19. (17/04129-9, 13/26798-9, 18/00265-8)