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The addictive effect of dynapenia and obesity (dynapenic obesity) on the incidence of disability and mortality among older adults: a comparison Between Brazil and England

Grant number: 15/20294-4
Support type:Scholarships abroad - Research
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Tiago da Silva Alexandre
Grantee:Tiago da Silva Alexandre
Host: Cesar Messias de Oliveira
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Local de pesquisa : University College London (UCL), England  
Associated research grant:14/50649-6 - SABE study: a longitudinal study of multiple cohorts on the elderly life and health conditions in the municipality of São Paulo - cohort 2015, AP.TEM

Abstract

Dynapenia, decreased muscle strength related to age, and obesity are major risk factors associated with physical functional decline and mortality in older adults. However, there is still little evidence that dynapenia and obesity, defined as dynapenic obesity, has additive effect in the incidence of disability and mortality in older adults. Thus, the aim of this study is to analyse the additive effect of dynapenia and abdominal obesity in incidence of disability in mobility, activities of daily living (ADL), instrumental activities of daily living (IADL) and mortality over 10 years follow-up comparing its effects among Brazilian and English older adults from the Health, Well-Being and Aging Study (SABE Study) and the English Longitudinal Study of Ageing (ELSA). For this, will be used data from the first wave of the SABE Study (2000), made up of 2,143 elderly, and from ELSA study (2002-2003), 7,246 elderly. The incidence of disabilityin mobility, ADL and IADL will be analysed by incidence density and mortality rates will be calculated. The additive effect of dynapenia and abdominal obesity in the incidence of disability in mobility, ADL and IADL will be analysed by Generalized Estimating Equations (GEE), Random effects models and Growth curve models and mortality with Cox proportional hazard models.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALEXANDRE, TIAGO DA SILVA; SCHOLES, SHAUN; FERREIRA SANTOS, JAIR LICIO; DE OLIVEIRA, CESAR. Dynapenic Abdominal Obesity as a Risk Factor for Worse Trajectories of ADL Disability Among Older Adults: The ELSA Cohort Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 74, n. 7, p. 1112-1118, JUL 2019. Web of Science Citations: 1.
ALEXANDRE, TIAGO DA SILVA; SCHOLES, SHAUN; FERREIRA SANTOS, JAIR LICIO; DE OLIVEIRA DUARTE, YEDA APARECIDA; DE OLIVEIRA, CESAR. The combination of dynapenia and abdominal obesity as a risk factor for worse trajectories of IADL disability among older adults. Clinical Nutrition, v. 37, n. 6, A, p. 2045-2053, DEC 2018. Web of Science Citations: 3.
ALEXANDRE, T. DA SILVA; SCHOLES, S.; FERREIRA SANTOS, J. L.; DE OLIVEIRA DUARTE, Y. A.; DE OLIVEIRA, C. Dynapenic Abdominal Obesity Increases Mortality Risk Among English and Brazilian Older Adults: A 10-Year Follow-Up of the ELSA and SABE Studies. Journal of Nutrition Health & Aging, v. 22, n. 1, p. 138-144, JAN 2018. Web of Science Citations: 2.

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