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Age-period-cohort effects of dynapenic obesity in mobility and lower body functioning among older English adults aged 50 and older

Grant number: 19/22074-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 02, 2020
Effective date (End): September 01, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Tiago da Silva Alexandre
Grantee:Roberta de Oliveira Máximo
Supervisor abroad: Cesar Messias de Oliveira
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Local de pesquisa : University College London (UCL), England  
Associated to the scholarship:17/26377-4 - Sex differences in the effect of Dynapenic Abdominal Obesity on the trajectories of mobility decline and lower extremity function in people over 50 years, BP.DR

Abstract

Obesity and dynapenia are separated factors for the decline in mobility and lower limb function in elderly people. Besides that, those who present a combination of abdominal obesity and dynapenia evolve with worse closures of health than those who only own abdominal obesity or dynapenia. However, few evidences are showing that there is such effect age, period, and cohort of dynapenic abdominal obesity over the mobility and lower limb function in elderly people. Furthermore, recent data may not reflect the current populational trend. Thus, the objectives of the present proposal are to analyze the age, period, and cohort effects of the dynapenic abdominal obesity over 1) the decline in mobility; 2) the decline in lower limb function, and 3) analyze the differences between sexes. For that, thanks to a partnership of the present proposal's advisor with the Department of Epidemiology and Public Health of the University College London (UCL), longitudinal data and different cohorts from English Longitudinal Study of Aging - ELSA will be used. The baseline of the study will be the wave of 2004/2005. In order to estimate the age, period, and cohort effects, cohort data 3, 4, 6, and 7 will also be used. The final sample for analysis of the decline in mobility will be composed by 13.473 participants of ELSA, and 11.548 for the decline in lower limb function. Mobility will be assessed by the walking speed in meters/second, and the lower limb function will be evaluated by Short Physical Performance Battery (SPPB). Abdominal obesity will be defined for values of waist circumference > 102 cm for men, and > 88 cm for women, and dynapenia for values of handgrip strength < 26 kg for men, and < 16 kg for women. The participants will be classified as (0) non-abdominal obese/non-dynapenic; (1) abdominal obese/non-dynapenic; (2) non-abdominal obese/dynapenic, and (3) dynapenic abdominal obese. Age-Period-Cohort models will be adopted in order to analyze the effect of dynapenic abdominal obesity under the decline in mobility and lower limb function.