FUNGAL MICROBIOME IN HUMAN TUMOURS

• Grant number: 18/02972-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2018
• End date: July 31, 2021
• Field of knowledge: Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
• Principal Investigator: Israel Tojal da Silva
• Grantee: Bruno Spinetti Moda
• Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil

Abstract

The human microbiome is the group established between the interactions of body sites and the microbes communities that reside within. With the advances in molecular technologies, the existence of a great microorganisms diversity that wasn't detected before was revealed. Thus, new evidence of the role of microorganisms in host health was emerging. The study of the interaction between microbiome and cancer is very promising and may contribute to the understanding of the development of the disease, although the majority of the research focuses only on the bacteria within the microbiome. Other members, like the fungi, are neglected due to the minor contribution to the whole human microbiome, but their importance to the human health is well defined and also may be related to inflammatory diseases, but its cancer association is yet poor explored. This work intends to perform the study of the fungal microbiome related to types of human cancer located in regions more exposed to the external environment, looking to identifying the fungal diversity and its tumorigenesis contribution.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ALBUQUERQUE, GABRIELA E.; MODA, BRUNO S.; SERPA, MARIANNA S.; BRANCO, GABRIELA P.; DEFELICIBUS, ALEXANDRE; TAKENAKA, ISABELLA K. T. M.; DE AMORIM, MARIA G.; MIOLA, ELIZABETH C.; MARTINS, VALQUIRIA C. A.; TORRES, KATIA L.; et al. Evaluation of Bacteria and Fungi DNA Abundance in Human Tissues. GENES, v. 13, n. 2, p. 11-pg., 2022-02-01. (18/02972-3, 14/26897-0, 18/14267-2)