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Study of the regulation of eNOS Tyr81 phosphorylation

Grant number: 18/10414-0
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 01, 2018
Effective date (End): August 31, 2019
Field of knowledge:Biological Sciences - Pharmacology - Cardiorenal Pharmacology
Principal researcher:Gilberto de Nucci
Grantee:Alberto Fernando Oliveira Justo
Supervisor abroad: Ingrid Fleming
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Goethe University Frankfurt, Germany  
Associated to the scholarship:16/09539-8 - Pharmacological, eletrophysiological and morphological characterization of a novel tetrodotoxin-resistant sodium channel coupled to corpus cavernosum of snakes, BP.DD

Abstract

The phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) on Tyr81 was shown to increase NO production and blood vessel relaxation in response to agonist stimulation. Although Src has been initially reported to phosphorylate this tyrosine residue, the regulation of the phosphorylation of this site remains largely unexplored. Preliminary work at the Institute for Vascular Signaling demonstrated that the tyrosine protein kinase ABL1 and the vascular endothelial protein tyrosine phosphatase (VE-PTP) modulate the phosphorylation of eNOS on Tyr81 in human endothelial cells in vitro. Further studies will establish the relevance of these findings for the modulation of NO-dependent vascular responses in intact vessels. In addition, as ABL1, VE-PTP and eNOS have been shown to play a role in the modulation of endothelial barrier integrity, the effects of the inhibition of ABL1 and VE-PTP on vascular permeability will be determined. (AU)

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