Anti-cariogenic effect of a hybrid coating associated or not to sodium fluoride or sodium fluoride plus stannous chloride on enamel

• Grant number: 18/06251-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: August 01, 2018
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Taís Scaramucci Forlin
• Grantee: Sávio José Cardoso Bezerra
• Supervisor: Anderson Takeo Hara
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Indiana University, United States
• Associated to the scholarship: 17/13855-5 - Anti-erosive and anti-abrasive effect of a hybrid film associated or not with sodium fluoride or sodium fluoride and stannous chloride in enamel and dentin, BP.DR

Abstract

The aim of this study is incorporate fluoride, or the combination of fluoride and tin chloride, encapsulated in nano tubes of halloysite and bentonite, into a hybrid coating and later test the anti-caries preventive potential of these films on enamel. Enamel specimens (5 mm x 5 mm), obtained from bovine teeth, will be prepared. The enamel specimens will be treated with the polymeric coatings (n=10), then they will have their surface divided into two parts (5 mm x 2,5 mm each), one where the treatments will be applied and then submitted to the cariogenic challenge (under treatment), and the other that will be submitted only to the cariogenic challenge (adjacent to treatment). After, all the treated specimens will be fixed vertically in metal devices, and immersed in 24-well culture plates to be submitted to a cariogenic challenge, using a biofilm model for 5 days. The response variable will be the mineral content change, measured by transverse microradiography, and expressed by the total mineral loss and average lesion depth. Data will be statistically analyzed using appropriate methods (± = 0.05).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SÁVIO JOSÉ CARDOSO BEZERRA; ÍTALLO EMÍDIO LIRA VIANA; IDALINA VIEIRA AOKI; SIMONE DUARTE; ANDERSON TAKEO HARA; TAÍS SCARAMUCCI. In-vitro evaluation of the anti-cariogenic effect of a hybrid coating associated with encapsulated sodium fluoride and stannous chloride in nanoclays on enamel. Journal of Applied Oral Science, v. 30, 2022-05-02. (17/14691-6, 18/06251-9)