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Protective effect of solutions containing polymethacrylate of enamel erosive wear

Grant number: 18/25723-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Alessandra Buhler Borges
Grantee:Luís Felipe Oliveira da Silva
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


The prevalence of dental erosion has increased in recent years, mainly due to changes in dietary and behavioral habits of general populations. Considering the irreversible nature of this condition, early diagnosis and the adoption of preventive and therapeutic measures are very important. In addition, a greater concern with oral hygiene has been noticed. However, brushing with abrasive products associated with the frequent consumption of acidic beverages can lead to increased wear of the tooth surface. Recently, the ability of organic and inorganic polymers to reduce dental erosion has been evaluated. The anti-erosive potential of the polymers is due to their compatibility with dental structures and the ability to form a protective film on the surface. This study aims to investigate the efficacy of the addition of a polymethacrylate copolymer (Eudragit E100, Essen, Germany) to solutions simulating mouth rinses, as well as the effect of its association with sodium fluoride (NaF) and NaF associated with stannous chloride (NaF + Sn) in protecting the dental structures against erosive challenges associated to toothbrush abrasion. The solutions will be tested in a de-remineralizing erosive cycling model with two treatments per day for five days using bovine enamel specimens. Abrasion will be performed after the treatments using a slurry containing fluoride dentifrice and artificial saliva in the ratio 1:3 (weight). The acid challenge will be performed with 0.3% citric acid (pH = 2.6), four times a day (5 min). The initial erosion will be analyzed on the first day of cycling by superficial microhardness and the surface loss will be analyzed after the end of the cycling by contact profilometry. The data will be analyzed according to the appropriate statistics.

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