SEASONAL RELATIONSHIP BETWEEN IMMUNOCOMPETENCE, STERIODS AND STRESS RESPONSE IN ECTOTERMS

• Grant number: 18/00406-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2018
• End date: December 31, 2020
• Field of knowledge: Biological Sciences - Physiology - Compared Physiology
• Principal Investigator: Fernando Ribeiro Gomes
• Grantee: Carla Bonetti Madelaire
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 14/16320-7 - Impacts of climate/environmental change on the fauna: an integrative approach, AP.PFPMCG.TEM
• Associated scholarship(s): 19/13164-8 - Stress markers in anurans: How stress stimuli affects saliva glucocorticoids levels and seasonality affects brain receptors, BE.EP.PD

Abstract

Steroid hormones mediate transitions between life history stages in vertebrates due to their broad effect on their physiology and behavior. Species that display seasonal reproduction increase their androgens (AN), estradiol (E) and glucocorticoids (GC) during this period in order to mediate and facilitate reproduction. Additionally, steroid concentration and time of exposure along with individual energetic state regulate immunocompetence. Reproduction and immunity are energetic expensive and the differential cost of reproduction between males and females could affect how sexes invest in immunocompetence. The GC are mediators of the stress response, however the continuum activation of the adrenals to produce corticosterone could result on inhibition of reproductive steroids, suppressing reproduction. Vertebrates that display drastic transitions among life history stages are ideal models for integrative studies between steroids, energetic state and immunocompetence, and to identify if there is differential investment on immunity among sexes during reproductive period. Additionally, commercial anuran species are ideal to test experimentally the functional relationship between GC plasma levels, CG receptors in the brain and immunocompetence.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PRADO, DEBORA M. A.; GOMES, FERNANDO R.; MADELAIRE, CARLA B.. Effects of corticosterone treatment and wound healing on reproductive traits of American bullfrogs. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, v. 335, n. 2, JAN 2021. (18/00406-0, 18/20224-4)

PRADO, DEBORA M. A.; GOMES, FERNANDO R.; MADELAIRE, CARLA B.. Effects of corticosterone treatment and wound healing on reproductive traits of American bullfrogs. OURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOG, v. 335, n. 2, p. 11-pg., 2021-01-07. (18/00406-0, 18/20224-4)

MADELAIRE, CARLA B.; ZENA, LUCAS A.; DILLON, DANIELLE; SILVA, DIEGO P.; HUNT, KATHLEEN E.; BUCK, C. LOREN; BICEGO, KENIA C.; GOMES, FERNANDO R.. ho Rules Over Immunology? Seasonal Variation in Body Temperature, Steroid Hormones, and Immune Variables in a Tegu Lizar. INTEGRATIVE AND COMPARATIVE BIOLOGY, v. 61, n. 5, p. 1867-1880, NOV 2021. (12/24206-4, 18/00406-0, 15/04849-6, 14/16320-7, 19/13164-8, 17/01652-2)

GOMES, FERNANDO RIBEIRO; MADELAIRE, CARLA BONETTI; MORETTI, EDUARDO HERMOGENES; MONTEIRO TITON, STEFANNY CHRISTIE; ASSIS, VANIA REGINA. Immunoendocrinology and Ecoimmunology in Brazilian Anurans. INTEGRATIVE AND COMPARATIVE BIOLOGY, v. N/A, p. 17-pg., 2022-04-12. (15/23801-4, 20/09399-7, 11/03030-2, 14/16320-7, 19/24950-4, 18/00406-0)

GIORGI BARSOTTI, ADRIANA MARIA; MADELAIRE, CARLA BONETTI; WAGENER, CARLA; TITON JR, BRAZ; MEASEY, JOHN; GOMES, FERNANDO RIBEIRO. Challenges of a novel range: Water balance, stress, and immunity in an invasive toad. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 253, MAR 2021. (18/00406-0, 14/16320-7, 18/23661-6)

MADELAIRE, CARLA B.; BARSOTTI, ADRIANA M. G.; WAGENER, CARLA; SUGANO, YURI Y. VIEIRA; BAXTER-GILBERT, JAMES; GOMES, FERNANDO R.; MEASEY, JOHN. Challenges of dehydration result in a behavioral shift in invasive toads. BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY, v. 74, n. 7, JUN 14 2020. (18/23661-6, 18/00406-0, 14/16320-7)

MADELAIRE, CARLA B.; SILVA, DIEGO P.; TITON, STEFANNY C. M.; LAMADRID-FERIS, FARIDE; FLORESTE, FELIPE R.; TITON JR, BRAZ; GOMES, FERNANDO R.. Contrasting effects of transdermal and implant corticosterone treatments in the American bullfrog wound healing. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, v. 378, n. 1882, p. 11-pg., 2023-07-31. (14/16320-7, 18/00406-0)