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Artificial lichens and the integration of products with high added value to a biorefinery

Grant number: 18/01386-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2018
Effective date (End): February 28, 2022
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Messias Borges Silva
Grantee:Savienne Maria Fiorentini Elerbrock Zorn
Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM


The use of microbial communities has been considered one of the new exponents in the field of bioprocess engineering. Lichen-type biofilms, composed of microalgae and filamentous fungi, are an example of a symbiotic relationship able to sum the biotechnological potentials of each species present in the structure. Considering the fact that filamentous fungi, such as Mucor circinelloides, and microalgae, such as Chlorella vulgaris, are already consolidated in the context of production of lipids and other value-added metabolites, we propose herein to study the interaction of the aforementioned species in a lichenized form. Also included in this proposal is the use of the microalgae Nephroselmis viridis, recently isolated in Brazilian waters, which is also reported as a producer of high value metabolites, such as lipids and carotenoids. The current doctoral proposal aims (i) the study of interaction and formation of structures of the lichen form between M. circinelloides/C. vulgaris and M. circinelloides/N. viridis, followed by (ii) optimization of the culture medium with determination of the most appropriate conditions for formation of lichen-like structures, i.e., that promote high values of cellular integration in submerged lichen medium, with (iii) integration of this structure to the production of polyunsaturated lipids and carotenoids. Finally, the growth capacity of the submerged structure will be tested (iv) using co-products typical of the bioethanol and biodiesel industries. This proposal is linked to the thematic project "From the cellular plant to the integrated biodiesel-bioethanol biorefinery: a systemic approach applied to complex problems in micro and macro scales" (BIOEN FAPESP 2016/10636-8), with the involvement of the following institutions UFSCAR, EEL/ USP, UNICAMP, and EMBRAPA. In the linked thematic project, the challenges for the viability of integrated biorefineries have been addressed considering the system in all its dimensions. In particular the present proposal takes in consideration the consolidated experience of the Biocatalysis Laboratory at EEL/USP in axenic cultivation of the fungus M. circinelloides and microalgae, providing the necessary base for the formation of artificial lichens capable of integrating products of high added value to a G1-G2 biorefinery. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZORN, SAVIENNE M. F. E.; REIS, CRISTIANO E. R.; SILVA, MESSIAS B.; HU, BO; DE CASTRO, HEIZIR F.. Consortium Growth of Filamentous Fungi and Microalgae: Evaluation of Different Cultivation Strategies to Optimize Cell Harvesting and Lipid Accumulation. ENERGIES, v. 13, n. 14, . (16/10636-8, 18/01386-3, 17/12908-8)
ZORN, SAVIENNE M. F. E.; REIS, CRISTIANO E. R.; BENTO, HEITOR B. S.; DE CARVALHO, ANA KARINE F.; SILVA, MESSIAS B.; DE CASTRO, HEIZIR F.. In Situ Transesterification of Marine Microalgae Biomass via Heterogeneous Acid Catalysis. BioEnergy Research, v. 13, n. 4, . (17/12908-8, 18/01386-3, 16/10636-8)
ZORN, SAVIENNE; CARVALHO, ANA; BENTO, HEITOR; GAMBARATO, BRUNO; PEDRO, GUILHERME; DA SILVA, ANA; GONCALVES, RHYAN; DA ROS, PATRICIA; SILVA, MESSIAS. Use of Fungal Mycelium as Biosupport in the Formation of Lichen-like Structure: Recovery of Algal Grown in Sugarcane Molasses for Lipid Accumulation and Balanced Fatty Acid Profile. MEMBRANES, v. 12, n. 3, p. 15-pg., . (16/10636-8, 20/15513-7, 18/01386-3)
ZORN, SAVIENNE M. F. E.; DA SILVA, ANA PAULA T.; BREDDA, EDUARDO H.; BENTO, HEITOR B. S.; PEDRO, GUILHERME A.; CARVALHO, ANA KARINE F.; SILVA, MESSIAS BORGES; DA ROS, PATRICIA C. M.. In Situ Transesterification of Microbial Biomass for Biolubricant Production Catalyzed by Heteropolyacid Supported on Niobium. ENERGIES, v. 15, n. 4, p. 12-pg., . (16/10636-8, 16/18909-3, 18/01386-3, 20/15513-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ZORN, Savienne Maria Fiorentini Elerbrock. Artificial lichens and the integration of high value-added products into a biorefinery. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Engenharia de Lorena (EEL/ASDI) Lorena.

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