Development and characterization of solid dispersions of niclosamide

• Grant number: 18/00273-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2018
• Effective date (End): June 30, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Gabriel Lima Barros de Araujo
• Grantee: Mariana Ribeiro Gubitoso
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Niclosamide is an effective anthelmintic agent that in recent years has been repositioned for use in the treatment of tumors and viral infections. Its low solubility in water, however, may compromise its effective use and performance in preclinical and clinical trials. The present project aims to explore possible alternatives through the research and development of solid dispersions for the reformulation of this drug, in order to indicate ways to improve its solubility. (AU)