| Grant number: | 18/11319-1 |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| Effective date (Start): | July 01, 2018 |
| Effective date (End): | December 31, 2019 |
| Field of knowledge: | Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms |
| Principal researcher: | Antonio Rossi Filho |
| Grantee: | Maíra Pompeu Martins |
| Home Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Associated research grant: | 14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi, AP.TEM |
Abstract Dermatophyte and host interaction involves a variety of molecular signals, generated by both the host and the dermatophyte, that allow either installation or its removal by the host. Mechanical signaling, skin pH, adhesion, nutrient uptake, installation, development, and maintenance in the host are part of this signaling. The transduction of molecular signals generated by the insufficiency of nutrients abundant in nitrogen leads to the derepression of several proteolytic enzymes with optimum pH in both the acid and alkaline regions, allowing the use of keratin as a source of nitrogen over a broad spectrum of ambient pH. This event leading to the expression of non-specific proteases and keratinases and secretion in the external environment is closely linked to the pathogenicity of the dermatophytes. Thus, characterizing the proteolytic and secretory system of these enzymes may contribute significantly to the understanding of the pathogenicity of these dermatophytes. Comparative studies among dermatophytes with fully sequenced genomes may help to understand their infectious specificity. | |
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