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Transcription factors and cell signaling.

Grant number: 18/11319-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal researcher:Antonio Rossi Filho
Grantee:Maíra Pompeu Martins
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi, AP.TEM

Abstract

Dermatophyte and host interaction involves a variety of molecular signals, generated by both the host and the dermatophyte, that allow either installation or its removal by the host. Mechanical signaling, skin pH, adhesion, nutrient uptake, installation, development, and maintenance in the host are part of this signaling. The transduction of molecular signals generated by the insufficiency of nutrients abundant in nitrogen leads to the derepression of several proteolytic enzymes with optimum pH in both the acid and alkaline regions, allowing the use of keratin as a source of nitrogen over a broad spectrum of ambient pH. This event leading to the expression of non-specific proteases and keratinases and secretion in the external environment is closely linked to the pathogenicity of the dermatophytes. Thus, characterizing the proteolytic and secretory system of these enzymes may contribute significantly to the understanding of the pathogenicity of these dermatophytes. Comparative studies among dermatophytes with fully sequenced genomes may help to understand their infectious specificity.

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINEZ-ROSSI, NILCE M.; PERES, NALU T. A.; BITENCOURT, TAMIRES A.; MARTINS, MAIRA P.; ROSSI, ANTONIO. State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms. JOURNAL OF FUNGI, v. 7, n. 8 AUG 2021. Web of Science Citations: 0.
BITENCOURT, TAMIRES A.; NEVES-DA-ROCHA, JOAO; MARTINS, MAIRA P.; SANCHES, PABLO R.; LANG, ELZA A. S.; BORTOLOSSI, JULIO C.; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE M. StuA-Regulated Processes in the Dermatophyte Trichophyton rubrum: Transcription Profile, Cell-Cell Adhesion, and Immunomodulation. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, JUN 8 2021. Web of Science Citations: 1.
ROSSI, ANTONIO; MARTINS, MAIRA P.; BITENCOURT, TAMIRES A.; PERES, NALU T. A.; ROCHA, CARLOS H. L.; ROCHA, FLAVIANE M. G.; NEVES-DA-ROCHA, JOAO; LOPES, MARCOS E. R.; SANCHES, PABLO R.; BORTOLOSSI, JULIO C.; MARTINEZ-ROSSI, NILCE M. Reassessing the Use of Undecanoic Acid as a Therapeutic Strategy for Treating Fungal Infections. Mycopathologia, v. 186, n. 3, p. 327-340, JUN 2021. Web of Science Citations: 0.
ROSSI, ANTONIO; MARTINS, MAIRA P.; BITENCOURT, TAMIRES A.; PERES, NALU T. A.; ROCHA, CARLOS H. L.; ROCHA, FLAVIANE M. G.; NEVES-DA-ROCHA, JOAO; LOPES, MARCOS E. R.; SANCHES, PABLO R.; BORTOLOSSI, JULIO C.; MARTINEZ-ROSSI, NILCE M. Reassessing the Use of Undecanoic Acid as a Therapeutic Strategy for Treating Fungal Infections. Mycopathologia, v. 186, n. 3 APR 2021. Web of Science Citations: 0.
DA SILVA, LARISSA GOMES; MARTINS, MAIRA POMPEU; SANCHES, PABLO RODRIGO; DE AGUIAR PERES, NALU TEIXEIRA; MARTINEZ-ROSSI, NILCE MARIA; ROSSI, ANTONIO. Saline stress affects the pH-dependent regulation of the transcription factor PacC in the dermatophyteTrichophyton interdigitale. Brazilian Journal of Microbiology, v. 51, n. 4 JUN 2020. Web of Science Citations: 0.
MARTINS, MAIRA POMPEU; ROSSI, ANTONIO; SANCHES, PABLO RODRIGO; BORTOLOSSI, JULIO CESAR; MARTINEZ-ROSSI, NILCE MARIA. Comprehensive analysis of the dermatophyte Trichophyton rubrum transcriptional profile reveals dynamic metabolic modulation. Biochemical Journal, v. 477, n. 5, p. 873-885, MAR 2020. Web of Science Citations: 0.
MAÍRA POMPEU MARTINS; NILCE MARIA MARTINEZ-ROSSI; PABLO RODRIGO SANCHES; ANTONIO ROSSI. The PAC-3 transcription factor critically regulates phenotype-associated genes in Neurospora crassa. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 3, p. -, 2020. Web of Science Citations: 0.
MARTINS, MAIRA P.; SILVA, LARISSA G.; ROSSI, ANTONIO; SANCHES, PABLO R.; SOUZA, LARISSA D. R.; MARTINEZ-ROSSI, NILCE M. Global Analysis of Cell Wall Genes Revealed Putative Virulence Factors in the Dermatophyte Trichophyton rubrum. FRONTIERS IN MICROBIOLOGY, v. 10, SEP 19 2019. Web of Science Citations: 2.
MARTINS, MAIRA POMPEU; MARTINEZ-ROSSI, NILCE M.; SANCHES, PABLO R.; GOMES, ERISTON VIEIRA; BERTOLINI, MARIA CELIA; PEDERSOLI, WELLINGTON R.; SILVA, ROBERTO NASCIMENTO; ROSSI, ANTONIO. The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi. FRONTIERS IN MICROBIOLOGY, v. 10, SEP 4 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.