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Transcription factors and cell signaling.

Grant number: 18/11319-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date: July 01, 2018
End date: December 31, 2019
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Antonio Rossi Filho
Grantee:Maíra Pompeu Martins
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi, AP.TEM

Abstract

Dermatophyte and host interaction involves a variety of molecular signals, generated by both the host and the dermatophyte, that allow either installation or its removal by the host. Mechanical signaling, skin pH, adhesion, nutrient uptake, installation, development, and maintenance in the host are part of this signaling. The transduction of molecular signals generated by the insufficiency of nutrients abundant in nitrogen leads to the derepression of several proteolytic enzymes with optimum pH in both the acid and alkaline regions, allowing the use of keratin as a source of nitrogen over a broad spectrum of ambient pH. This event leading to the expression of non-specific proteases and keratinases and secretion in the external environment is closely linked to the pathogenicity of the dermatophytes. Thus, characterizing the proteolytic and secretory system of these enzymes may contribute significantly to the understanding of the pathogenicity of these dermatophytes. Comparative studies among dermatophytes with fully sequenced genomes may help to understand their infectious specificity.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSI, ANTONIO; MARTINS, MAIRA P.; BITENCOURT, TAMIRES A.; PERES, NALU T. A.; ROCHA, CARLOS H. L.; ROCHA, FLAVIANE M. G.; NEVES-DA-ROCHA, JOAO; LOPES, MARCOS E. R.; SANCHES, PABLO R.; BORTOLOSSI, JULIO C.; et al. Reassessing the Use of Undecanoic Acid as a Therapeutic Strategy for Treating Fungal Infections. Mycopathologia, v. 186, n. 3, p. 327-340, . (15/23435-8, 19/22596-9, 18/15458-6, 18/11319-1, 09/08411-4)
MARTINS, MAIRA POMPEU; MARTINEZ-ROSSI, NILCE M.; SANCHES, PABLO R.; GOMES, ERISTON VIEIRA; BERTOLINI, MARIA CELIA; PEDERSOLI, WELLINGTON R.; SILVA, ROBERTO NASCIMENTO; ROSSI, ANTONIO. The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi. FRONTIERS IN MICROBIOLOGY, v. 10, . (16/04274-6, 18/11319-1, 14/03847-7)
LOPES, MARCOS E. R.; BITENCOURT, TAMIRES A.; SANCHES, PABLO R.; MARTINS, MAIRA P.; OLIVEIRA, VANDERCI M.; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE M.. Alternative Splicing in Trichophyton rubrum Occurs in Efflux Pump Transcripts in Response to Antifungal Drugs. JOURNAL OF FUNGI, v. 8, n. 8, p. 12-pg., . (18/11319-1, 15/23435-8, 19/22596-9)
MAÍRA POMPEU MARTINS; NILCE MARIA MARTINEZ-ROSSI; PABLO RODRIGO SANCHES; ANTONIO ROSSI. The PAC-3 transcription factor critically regulates phenotype-associated genes in Neurospora crassa. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 3, . (18/11319-1, 14/03847-7)
MARTINS, MAIRA P.; SILVA, LARISSA G.; ROSSI, ANTONIO; SANCHES, PABLO R.; SOUZA, LARISSA D. R.; MARTINEZ-ROSSI, NILCE M.. Global Analysis of Cell Wall Genes Revealed Putative Virulence Factors in the Dermatophyte Trichophyton rubrum. FRONTIERS IN MICROBIOLOGY, v. 10, . (10/15017-8, 14/03847-7, 18/11319-1)
CRUZ, ALINE H. S.; SANTOS, RODRIGO S. S.; MARTINS, MAIRA P.; PERES, NALU T. A.; TREVISAN, GLAUCE L. L.; MENDES, NIEGE S. S.; MARTINEZ-ROSSI, NILCE M. M.; ROSSI, ANTONIO. Relevance of Nutrient-Sensing in the Pathogenesis of Trichophyton rubrum and Trichophyton interdigitale. FRONTIERS IN FUNGAL BIOLOGY, v. 3, p. 14-pg., . (19/22596-9, 18/11319-1, 09/08411-4)
BITENCOURT, TAMIRES A.; NEVES-DA-ROCHA, JOAO; MARTINS, MAIRA P.; SANCHES, PABLO R.; LANG, ELZA A. S.; BORTOLOSSI, JULIO C.; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE M.. StuA-Regulated Processes in the Dermatophyte Trichophyton rubrum: Transcription Profile, Cell-Cell Adhesion, and Immunomodulation. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (18/15458-6, 15/23435-8, 18/11319-1, 19/22596-9)
DA SILVA, LARISSA GOMES; MARTINS, MAIRA POMPEU; SANCHES, PABLO RODRIGO; DE AGUIAR PERES, NALU TEIXEIRA; MARTINEZ-ROSSI, NILCE MARIA; ROSSI, ANTONIO. Saline stress affects the pH-dependent regulation of the transcription factor PacC in the dermatophyteTrichophyton interdigitale. Brazilian Journal of Microbiology, v. 51, n. 4, . (09/08411-4, 10/15017-8, 14/03847-7, 18/11319-1)
MARTINEZ-ROSSI, NILCE M.; PERES, NALU T. A.; BITENCOURT, TAMIRES A.; MARTINS, MAIRA P.; ROSSI, ANTONIO. State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms. JOURNAL OF FUNGI, v. 7, n. 8, . (15/23435-8, 18/11319-1, 19/22596-9)
MARTINS, MAIRA POMPEU; ROSSI, ANTONIO; SANCHES, PABLO RODRIGO; BORTOLOSSI, JULIO CESAR; MARTINEZ-ROSSI, NILCE MARIA. Comprehensive analysis of the dermatophyte Trichophyton rubrum transcriptional profile reveals dynamic metabolic modulation. Biochemical Journal, v. 477, n. 5, p. 873-885, . (18/11319-1, 14/03847-7)
ROCHA, CARLOS H. LOPES; ROCHA, FLAVIANE M. GALVAO; BITENCOURT, TAMIRES A.; MARTINS, MAIRA P.; SANCHES, PABLO R.; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE M.. Synergism between the Antidepressant Sertraline and Caspofungin as an Approach to Minimise the Virulence and Resistance in the Dermatophyte Trichophyton rubrum. JOURNAL OF FUNGI, v. 8, n. 8, p. 13-pg., . (18/11319-1, 15/23435-8, 19/22596-9)