| Grant number: | 14/03847-7 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | February 01, 2015 |
| End date: | April 30, 2020 |
| Field of knowledge: | Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms |
| Principal Investigator: | Nilce Maria Martinez-Rossi |
| Grantee: | Nilce Maria Martinez-Rossi |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
| Principal investigators | Antonio Rossi Filho |
| Associated researchers: | Elza Akie Sakamoto Lang ; Gabriela Felix Persinoti ; Nalu Teixeira de Aguiar Peres ; Rafael Silva Rocha |
| Associated scholarship(s): | 18/15458-6 - Alternative splicing in genes coding for HSPs as a response to antifungals in the dermatophyte Trichophyton rubrum.,
BP.IC 18/11319-1 - Transcription factors and cell signaling., BP.PD |
Abstract
Dermatophytes are filamentous fungi that use keratin as a nutrient source during infection of skin, nail and hair. Dermatophyte adherence and secretion of enzymes are key factors in the colonization of the host tissues, which can be regulated in response to phosphate levels, different carbon and nitrogen sources, and ambient pH. Dermatophytoses constitute one of the most common fungal infections. Despite its clinical importance, the molecular aspects concerning colonization, influence of various environmental factors, gene regulation of enzyme secretion, and drug resistance are not yet fully elucidated. The main goal of this proposal is the understanding of mechanisms used by dermatophytes, especially Trichophyton rubrum, during the colonization of the host tissue, and the signaling pathways involved in sensing, and in transduction of molecular signals in response to the environment. It is intended to assess the relationship between alternative splicing events and response to cytotoxic drugs; to identify genes and non-coding RNAs potentially involved in the pathogenicity of dermatophytes, and to understand the molecular mechanisms involved in sensing and modulation of gene expression that allow fungi to survive under stressful environments, such as extremes of pH, nutrient deprivation, and interaction with host molecules in vitro. Thus, it is expected to reveal molecular mechanisms involved in gene expression regulation, as well as alternative forms of regulation involving ncRNA and mRNA isoforms required for dermatophytes adaptation to adverse environmental conditions such as antifungal drugs and interaction with the host as well as the relationship between different signaling and metabolic pathways that allow the survival of fungi under such conditions. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |