Analysis of gene pathways regulated by the HOXB2 gene in Glioblastoma

• Grant number: 17/24027-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2018
• End date: December 31, 2020
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Wilson Araújo da Silva Junior
• Grantee: Natália Volgarine Scaraboto Bonfa
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID
• Associated scholarship(s): 19/17348-6 - Identification of HOXB2 gene targets in Glioblastoma cell line by Promotor Capture Hi-C technique, BE.EP.MS

Abstract

HOX genes are a subgroup of the Homeobox family characterized by high degree of conservation among fungi, plants and animals. In mammals, there are 39 HOX genes distributed in four groups or clusters: HOXA, HOXB, HOXC and HOXD, located on chromosomes 2, 7, 17 and 12, respectively. HOX genes are transcription factors that act during embryonic development, regulating fundamental biological processes such as: proliferation, differentiation, migration, angiogenesis and apoptosis. Recent studies have indicated a tissue-specific expression profile of HOX genes in different tumor types, suggesting an important role in tumorigenesis. Previous analyses performed by our group demonstrated that 33 HOX genes are hyperexpressed in glioblastoma (GBM), which is considered the most aggressive tumor of the central nervous system. In addition, analysed data from public platforms indicated that patients with GBM and with high expression of HOXB2 have low survival. In this context, our main objective will be to evaluate, based on the information of its targets, the functional role of the HOXB2 gene in glioblastoma.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BONFA, Natália Volgarine Scaraboto. Analysis of gene pathways regulated by HOXB2 gene in glioblastoma. 2021. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.