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Changes in the glucose transporters expression in central nervous system: correlation between Type 3 Diabetes Mellitus and Alzheimer's Disease

Grant number: 18/12265-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2018
Effective date (End): November 30, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Maria Lucia Cardillo Corrêa Giannella
Grantee:Daniele Pereira dos Santos Bezerra
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/15603-0 - Unraveling mechanisms of glycemic control and chronic complications of Diabetes mellitus: contributions to human health, AP.TEM

Abstract

Epidemiological studies have shown that Diabetes Mellitus and Obesity are risk factors for the genesis and progression of Alzheimer's Disease. In the last decade, studies have demonstrated insulin resistance in some brain regions of patients with Alzheimer's Disease (AD), suggesting that impairment of glucose supply to neuronal cells may be a key element in the onset and progression of neurodegeneration in AD. In regions that are frequently involved in AD, such as the hippocampus, caudate nucleus and cerebellum, expression of GLUT4 and SGLT1 glucose transporters, encoded by the SLC2A4 and SLC5A1 genes, respectively, has been suggested. Expression of the glucose transporters have already been shown to be altered in peripheral tissues of individuals with insulin resistance and/or Diabetes. GLUT2, encoded by the SLC2A2 gene, is expressed in regions devoid of blood-brain barrier, such as the hypothalamus, and has also been related to the pathogenesis of AD. Also, recent studies suggest that epigenetic mechanisms can regulate the transcription of important genes in the pathophysiology of AD; we have already shown epigenetic changes in the SLC2A4 gene in muscle of diabetic rats, but nothing is known about this in the brain. Thus, the focus of the present project is to investigate, in areas of (post-mortem) brains of obese humans whether Diabetes alters the expression of SLC2A4/GLUT4, SLC2A2/GLUT2, SLC5A1/SGLT1, and of inflammatory markers. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS-BEZERRA, DANIELE P.; CAVALEIRO, ANA MERCEDES; SANTOS, ARITANIA SOUSA; SUEMOTO, CLAUDIA KIMIE; PASQUALUCCI, CARLOS AUGUSTO; JACOB-FILHO, WILSON; PARAIZO LEITE, RENATA ELAINE; PASSARELLI, MARISA; NAGAHASHI MARIE, SUELY KAZUE; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA. Alcohol Use Disorder is Associated with Upregulation of MicroRNA-34a and MicroRNA-34c in Hippocampal Postmortem Tissue. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, v. 45, n. 1, p. 64-68, JAN 2021. Web of Science Citations: 0.
DE MATOS, MOZANIA REIS; SANTOS-BEZERRA, DANIELE PEREIRA; DIAS CAVALCANTE, CRISTIANE DAS GRACAS; DE CARVALHO, JACIRA XAVIER; LEITE, JULIANA; JANUARIO NEVES, JOSE ANTONIO; ADMONI, SHARON NINA; PASSARELLI, MARISA; PARISI, MARIA CANDIDA; CORREA-GIANNELLA, MARIA LUCIA. Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 17, n. 9 MAY 2020. Web of Science Citations: 0.
MOZÂNIA REIS DE MATOS; DANIELE PEREIRA SANTOS-BEZERRA; MARIA LUCIA CORREA-GIANNELLA. Reproducibility of a nylon fishing line as a screening test for diabetic foot ulceration risk. Clinics, v. 75, p. -, 2020.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.