Unraveling mechanisms of glycemic control and chronic complications of Diabetes mellitus: contributions to human health

• Grant number: 16/15603-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2017
• End date: November 30, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ubiratan Fabres Machado
• Grantee: Ubiratan Fabres Machado
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Pesquisadores principais:(Últimos): Maria Lucia Cardillo Corrêa Giannella ; Marisa Passarelli
• Associated researchers: Beatriz D'Agord Schaan ; Suely Kazue Nagahashi Marie
• Associated research grant(s): 24/02780-8 - 92nd European Atherosclerosis Society Congress, AR.EXT
• Associated scholarship(s): 18/26013-5 - Contribution of lipotoxicity in the development of cognitive deficit in Diabetes mellitus Type 2 (T2D), BP.PD; 19/25306-1 - Study of microRNAs potentially regulators of GLUT4 expression in adipose tissue of type 2 diabetes obese mice, BP.IC; 18/00172-0 - Advanced glycation products, endoplasmic reticulum stress and the modulation of the reverse cholesterol transport in human arteries with different levels Atherosclerotic lesion, BP.PD; + associated scholarships 18/12265-2 - Changes in the glucose transporters expression in central nervous system: correlation between Type 3 Diabetes mellitus and Alzheimer's Disease, BP.PD; 17/19449-9 - MicroRNAs-mediated epigenetic regulation of GLUT4 protein (Slc2a4 gene) in skeletal muscle of mice with type 2 diabetes mellitus, BP.PD; 16/25155-5 - Role of neuroinflammation and histone deacetylases on mechanisms of transcription of the SLC2A4 gene in SH-SY5Y cells and hippocampal neurons of obese humans without and with diabetes, BP.PD; 13/02854-7 - Anti-inflammatory role of apolipoprotein A-IV in diabetes mellitus and its impact on macrophage reverse cholesterol transport: influence of advanced glycation, BP.PD - associated scholarships

Abstract

Diabetes Mellitus (DM) and its chronic complications are the greatest public health problem. It is a must to develop approaches that help to control glycemia and to reduce the incidence of complications. Target territories to develop complications, which will be focused on in this proposal, include kidney, cardiovascular system, brain (Alzheimer's Disease also referred to as DM3) and liver. This project aims to unravel molecular mechanism concerning glycemic control and the development of complications in DM1 and/or in DM2. For that, we will investigate mechanisms contributing to the development or improvement of: 1) glycemic control: GLUT4 regulation in animal models and inspiratory exercise in humans; 2) Diabetic Renal Disease: genetic susceptibility markers and renal tubular disease related to urinary molecular markers (cells from urinary sediment); 3) Cardiovascular Disease: focusing on Atherosclerosis and endothelial progenitor cells migration in humans, and Cardiomyopathy in animal model; 4) Alzheimer's Disease: focusing on glucose disposal for specific brain areas, based on the expression of glucose transporters (post mortem human brain); and 5) Hepatic Diseases: non-alcoholic fatty liver disease in animal model, and Mauriac Syndrome in DM1 subjects. Several methodologies will be adopted: in vivo, in vitro and in silico analyses; Molecular Biology techniques for evaluation of gene expression (transcriptional, translational and epigenetic regulations). We expect to yield a myriad of results capable of remarkably enriching knowledge of the area, and significantly contributing to the health of Diabetes Mellitus patients. (AU)

Scientific publications

(44)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MORI, ROSANA CRISTINA; SANTOS-BEZERRA, DANIELE PEREIRA; PELAES, TATIANA SOUZA; ADMONI, SHARON NINA; PEREZ, RICARDO VESSONI; MONTEIRO, MARIA BEATRIZ; MACHADO, CLEIDE GUIMARAES; QUEIROZ, MARCIA SILVA; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA. Variants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes. DIABETES-METABOLISM RESEARCH AND REVIEWS, v. 37, n. 1, JUN 2020. (16/15603-0)

SAWADA, MARIA ISABELA BLOISE ALVES CALDAS; SANTANA, MONIQUE DE FATIMA DE MELLO; VANCINI, MILENA GOMES; PASSARELLI, MARISA. Reopening Pandora's box: Is there a role for HDL in breast cancer?. SEMINARS IN CANCER BIOLOGY, v. 114, p. 15-pg., 2025-09-01. (21/02401-9, 16/15603-0, 19/18431-4)

FERREIRA, GUILHERME DA SILVA; GARCIA BOCHI, ANA PAULA; PINTO, PAULA RAMOS; DEL BIANCO, VANESSA; RODRIGUES, LETICIA GOMES; TEIXEIRA MORAIS, MYCHEL RAONY PAIVA; NAKANDAKARE, EDNA REGINA; MACHADO, UBIRATAN FABRES; CATANOZI, SERGIO; PASSARELLI, MARISA. Aerobic Exercise Training Prevents Insulin Resistance and Hepatic Lipid Accumulation in LDL Receptor Knockout Mice Chronically Fed a Low-Sodium Diet. NUTRIENTS, v. 13, n. 7, JUL 2021. (16/15603-0)

DAVID-SILVA, ALINE; ESTEVES, JOAO VICTOR; MORAIS, MYCHEL RAONY P. T.; FREITAS, HELAYNE SOARES; ZORN, TELMA MARIA; CORREA-GIANNELLA, MARIA LUCIA; MACHADO, UBIRATAN FABRES. Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice. DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, v. 13, p. 739-751, 2020. (16/15603-0, 11/09463-8, 17/19449-9)

SANTOS-BEZERRA, DANIELE P.; CAVALEIRO, ANA MERCEDES; SANTOS, ARITANIA SOUSA; SUEMOTO, CLAUDIA KIMIE; PASQUALUCCI, CARLOS AUGUSTO; JACOB-FILHO, WILSON; PARAIZO LEITE, RENATA ELAINE; PASSARELLI, MARISA; NAGAHASHI MARIE, SUELY KAZUE; MACHADO, UBIRATAN FABRES; et al. Alcohol Use Disorder is Associated with Upregulation of MicroRNA-34a and MicroRNA-34c in Hippocampal Postmortem Tissue. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, v. 45, n. 1, p. 64-68, JAN 2021. (18/12265-2, 16/15603-0)

MORI, ROSANA CRISTINA; SANTOS-BEZERRA, DANIELE PEREIRA; PELAES, TATIANA SOUZA; ADMONI, SHARON NINA; PEREZ, RICARDO VESSONI; MONTEIRO, MARIA BEATRIZ; MACHADO, CLEIDE GUIMARAES; QUEIROZ, MARCIA SILVA; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA. Variants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes. DIABETES-METABOLISM RESEARCH AND REVIEWS, v. 37, n. 1, p. 9-pg., 2020-06-21. (16/15603-0)

YONAMINE, CAIO Y.; ALVES-WAGNER, ANA B.; ESTEVES, V, JOAO; OKAMOTO, MARISTELA M.; CORREA-GIANNELLA, MARIA L.; GIANNELLA-NETO, DANIEL; MACHADO, UBIRATAN F.. Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control. Molecular and Cellular Endocrinology, v. 481, p. 26-34, FEB 5 2019. (12/20432-0, 16/15603-0, 13/26616-8, 12/04831-1)

MACHADO-LIMA, ADRIANA; LOPEZ-DIEZ, RAQUEL; IBORRA, RODRIGO TALLADA; PINTO, RAPHAEL DE SOUZA; DAFFU, GURDIP; SHEN, XIAOPING; NAKANDAKARE, EDNA REGINA; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA CARDILLO; SCHMIDT, ANN MARIE; et al. RAGE Mediates Cholesterol Efflux Impairment in Macrophages Caused by Human Advanced Glycated Albumin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 19, OCT 2020. (12/19112-0, 15/21072-5, 13/06800-9, 18/00172-0, 13/26256-1, 12/12088-7, 14/05951-6, 16/15603-0)

IBORRA, RODRIGO TALLADA; MACHADO-LIMA, ADRIANA; OKUDA, LIGIA SHIMABUKURO; PINTO, PAULA RAMOS; NAKANDAKARE, EDNA REGINA; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA; PICKFORD, RUSSELL; WOODS, TOM; BRIMBLE, MARGARET A.; et al. AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 32, n. 1, p. 1-10, JAN 2018. (12/19112-0, 13/26256-1, 16/15603-0, 12/12088-7, 13/02854-7, 15/21072-5)

GIACAGLIA, MARCIA B.; PIRES, VITORIA; SANTANA, MONIQUE F. M.; PASSARELLI, MARISA. Unraveling the Pleiotropic Role of High-Density Lipoproteins (HDLs) in Autoimmune Rheumatic Diseases. INTERNATIONAL JOURNAL OF RHEUMATOLOGY, v. 2024, p. 12-pg., 2024-11-14. (19/18431-4, 16/15603-0, 21/02401-9)

ESTEVES, J.; YONAMINE, C. Y.; GERLINGER-ROMERO, F.; PINTO-JUNIOR, D. C.; ENGUITA, F. J.; MACHADO, U. F.. Diabetes modulates microRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p expression in muscle: potential participation in GLUT4 repression. Diabetologia, v. 61, p. 2-pg., 2018-10-01. (16/15603-0, 17/19449-9)

SANTOS-BEZERRA, D. P.; SANTOS, A. S.; GUIMARAES, G. C.; ADMONI, S. N.; PEREZ, R. V.; PELAES, T. S.; MACHADO, C. G.; PASSARELLI, M.; MACHADO, U. F.; QUEIROZ, M. S.; et al. Increased serum expression of miR-518d-3p and miR-618 in individuals with type 1 diabetes with microvascular chronic complications. Diabetologia, v. 61, p. 1-pg., 2018-10-01. (12/04831-1, 16/15603-0)

SANTANA, MONIQUE F. M.; LIRA, AECIO L. A.; PINTO, RAPHAEL S.; MINANNI, CARLOS A.; SILVA, AMANDA R. M.; SAWADA, MARIA I. B. A. C.; NAKANDAKARE, EDNA R.; CORREA-GIANNELLA, MARIA L. C.; QUEIROZ, MARCIA S.; RONSEIN, GRAZIELLA E.; et al. Enrichment of apolipoprotein A-IV and apolipoprotein D in the HDL proteome is associated with HDL functions in diabetic kidney disease without dialysis. LIPIDS IN HEALTH AND DISEASE, v. 19, n. 1, p. 14-pg., 2020-09-14. (16/00696-3, 18/00172-0, 17/07725-1, 16/15603-0, 15/21072-5)

SAWADA, MARIA I. B. A. C.; FERREIRA, GUILHERME DA S.; PASSARELLI, MARISA. Cholesterol derivatives and breast cancer: oxysterols driving tumor growth and metastasis. BIOMARKERS IN MEDICINE, v. 14, n. 14, p. 4-pg., 2020-09-24. (16/15603-0, 19/18431-4)

YONAMINE, CAIO YOGI; PASSARELLI, MARISA; SUEMOTO, CLAUDIA KIMIE; PASQUALUCCI, CARLOS AUGUSTO; JACOB-FILHO, WILSON; ALVES, VENANCIO AVANCINI FERREIRA; MARIE, SUELY KAZUE NAGAHASHI; CORREA-GIANNELLA, MARIA LUCIA; BRITTO, LUIZ ROBERTO; MACHADO, UBIRATAN FABRES. Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons: Potential Involvement of Inflammation. CELLS, v. 12, n. 9, p. 21-pg., 2023-04-25. (16/15603-0, 16/25155-5)

ESTEVES, V, JOAO; YONAMINE, CAIO Y.; PINTO-JUNIOR, DANILO C.; GERLINGER-ROMERO, FREDERICO; ENGUITA, FRANCISCO J.; MACHADO, UBIRATAN F.. Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression. FRONTIERS IN ENDOCRINOLOGY, v. 9, SEP 12 2018. (16/15603-0, 12/20432-0, 12/15514-7, 17/19449-9)

SANTOS-BEZERRA, DANIELE P.; MACHADO-LIMA, ADRIANA; MONTEIRO, MARIA BEATRIZ; ADMONI, SHARON N.; PEREZ, RICARDO V.; MACHADO, CLEIDE G.; SHIMIZU, MARIA HELOIZA; CAVALEIRO, ANA M.; THIEME, KARINA; QUEIROZ, MARCIA S.; et al. Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients. Diabetes & Vascular Disease Research, v. 15, n. 1, p. 81-89, JAN 2018. (12/04831-1, 16/15603-0, 12/25490-8)

YONAMINE, CAIO Y.; PINHEIRO-MACHADO, ERIKA; MICHALANI, MARIA L.; ALVES-WAGNER, ANA B.; ESTEVES, JOAO V.; FREITAS, HELAYNE S.; MACHADO, UBIRATAN F.. Resveratrol Improves Glycemic Control in Type 2 Diabetic Obese Mice by Regulating Glucose Transporter Expression in Skeletal Muscle and Liver. Molecules, v. 22, n. 7, JUL 2017. (16/15603-0)

BARRETO-ANDRADE, JOAO NILTON; DE FATIMA, LUCIANA ALVES; CAMPELLO, RAQUEL SALDANHA; CIPRIANO GUEDES, JOSE AUGUSTO; DE FREITAS, HELAYNE SOARES; UBIRATAN FABRES MACHADO, MARISTELA MITIKO OKAMOTO. Estrogen Receptor 1 (ESR1) Enhances Slc2a4/GLUT4 Expression by a SP1 Cooperative Mechanism. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, v. 15, n. 12, p. 1320-1328, 2018. (16/15603-0, 15/18715-1)

MORI, ROSANA CRISTINA; DA SILVA, THAIS POCAS; CAMPELLO, RAQUEL SALDANHA; MACHADO, UBIRATAN FABRES. Carbenoxolone enhances peripheral insulin sensitivity and GLUT4 expression in skeletal muscle of obese rats: Potential participation of UBC9 protein. Life Sciences, v. 229, p. 157-165, JUL 15 2019. (16/15603-0)

SANTOS-BEZERRA, DANIELE P.; SANTOS, ARITANIA S.; GUIMARAES, GABRIEL C.; ADMONI, SHARON N.; PEREZ, V, RICARDO; MACHADO, CLEIDE G.; PELAES, TATIANA S.; PASSARELLI, MARISA; MACHADO, UBIRATAN F.; QUEIROZ, MARCIA S.; et al. Micro-RNAs 518d-3p and 618 Are Upregulated in Individuals With Type 1 Diabetes With Multiple Microvascular Complications. FRONTIERS IN ENDOCRINOLOGY, v. 10, JUN 12 2019. (16/15603-0)

MINANNI, CARLOS ANDRE; MACHADO-LIMA, ADRIANA; IBORRA, RODRIGO TALLADA; OKUDA, LIGIA SHIMABUKURO; PINTO, RAPHAEL DE SOUZA; MELLO SANTANA, MONIQUE DE FATIMA; DE ARAUJO LIRA, AECIO LOPES; NAKANDAKARE, EDNA REGINA; CARDILLO CORREA-GIANNELLA, MARIA LUCIA; PASSARELLI, MARISA. Persistent Effect of Advanced Glycated Albumin Driving Inflammation and Disturbances in Cholesterol Efflux in Macrophages. NUTRIENTS, v. 13, n. 10, OCT 2021. (17/18545-4, 12/19112-0, 16/15603-0, 12/12088-7, 18/00172-0, 15/21072-5)

SANTOS-BEZERRA, DANIELE P.; FILGUEIRAS, LUCIANO R.; MONTEIRO, MARIA BEATRIZ; ADMONI, SHARON N.; PEREZ, V, RICARDO; CAVALEIRO, ANA M.; MACHADO, CLEIDE G.; MACHADO, UBIRATAN F.; PASSARELLI, MARISA; JANCAR, SONIA; et al. Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes. Mediators of Inflammation, v. 2020, MAR 23 2020. (16/15603-0, 13/15719-0)

PINTO, RAPHAEL S.; FERREIRA, GUILHERME S.; SILVESTRE, GINA CAMILLO R.; SANTANA, MONIQUE DE FATIMA M.; NUNES, VALERIA S.; LEDESMA, LUCAS; PINTO, PAULA R.; DE ASSIS, SAYONARA IVANA S.; MACHADO, UBIRATAN F.; DA SILVA, ERASMO S.; et al. Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques. Diabetes & Vascular Disease Research, v. 19, n. 1, p. 9-pg., 2022-01-01. (18/00172-0, 16/15603-0, 15/21072-5)

FERREIRA, GUILHERME DA SILVA; CATANOZI, SERGIO; PASSARELLI, MARISA. Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review. ANTIOXIDANTS, v. 12, n. 3, p. 15-pg., 2023-03-01. (16/15603-0)

OKUDA, LIGIA SHIMABUKURO; IBORRA, RODRIGO TALLADA; RAMOS, PAULA; MACHADO, UBIRATAN FABRES; CORREA-GIANNELLA, MARIA LUCIA; PICKFORD, RUSSELL; WOODS, TOM; BRIMBLE, MARGARET ANNE; RYE, KERRY-ANNE; PASSARELLI, MARISA. Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages. Mediators of Inflammation, v. 2020, JAN 14 2020. (13/23392-1, 16/15603-0, 15/21072-5, 13/02854-7, 13/26256-1)

MONTEIRO, MARIA BEATRIZ; SANTOS-BEZERRA, DANIELE P.; PELAES, TATIANA S.; VAIDYA, VISHAL S.; CORREA-GIANNELLA, MARIA LUCIA. MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes. CLINICAL CHEMISTRY, v. 65, n. 11, p. 1458-1459, NOV 2019. (16/04935-2, 16/15603-0, 15/19000-6, 18/12265-2)

PINTO, PAULA RAMOS; YOSHINAGA, MARCOS Y.; DEL BIANCO, VANESSA; BOCHI, ANA PAULA; FERREIRA, GUILHERME S.; PINTO, ISABELLA F. D.; RODRIGUES, LETICIA G.; NAKANDAKARE, EDNA R.; OKAMOTO, MARISTELA M.; MACHADO, UBIRATAN F.; et al. Dietary sodium restriction alters muscle lipidomics that relates to insulin resistance in mice. Journal of Biological Chemistry, v. 296, JAN-JUN 2021. (16/15603-0, 13/07937-8, 15/21072-5)

ESTEVES, J. V.; AMENDOLA, L. S.; OKAMOTO, M. M.; MACHADO, U. F.. Could miR-295-3p be a novel epigenetic regulator of GLUT4?. Diabetologia, v. 65, n. SUPPL 1, p. 1-pg., 2022-09-01. (17/19449-9, 16/15603-0)

GARCIA BOCHI, ANA PAULA; FERREIRA, GUILHERME DA SILVA; DEL BIANCO, VANESSA; PINTO, PAULA RAMOS; RODRIGUES, LETICIA GOMES; TREVISANI, MAYARA DA SILVA; SHINOHARA FURUKAWA, LUZIA NAOKO; SOARES BISPO, KELY CRISTINA; DA SILVA, ALEXANDRE ALVES; PEREIRA VELOSA, ANA PAULA; et al. Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice. ANTIOXIDANTS, v. 11, n. 10, p. 16-pg., 2022-10-01. (16/15603-0)

SEKIYA, FELIPE SEITI; DA SILVA, CLARISSE PEREIRA NUNES; OBA-SHINJO, SUELI MIEKO; SANTOS-BEZERRA, DANIELE PEREIRA; RAVAGNANI, FELIPE GUSTAVO; PASQUALUCCI, CARLOS AUGUSTO; GIL, SAULO; GUALANO, BRUNO; BAPTISTA, MAURICIO DA SILVA; CORREA-GIANNELLA, MARIA LUCIA; et al. Identification of two patterns of mitochondrial DNA-copy number variation in postcentral gyrus during aging, influenced by body mass index and type 2 diabetes. Experimental Gerontology, v. 168, p. 8-pg., 2022-08-23. (17/13552-2, 20/02988-7, 20/08091-9, 13/07937-8, 16/15603-0)

THIEME, KARINA; VELOSO PEREIRA, BEATRIZ MARIA; DA SILVA, KAROLLINE S.; FABRE, NELLY T.; CATANOZI, SERGIO; PASSARELLI, MARISA; CORREA-GIANNELLA, MARIA LUCIA. Chronic advanced-glycation end products treatment induces TXNIP expression and epigenetic changes in glomerular podocytes in vivo and in vitro. Life Sciences, v. 270, APR 1 2021. (18/00573-4, 19/10583-0, 16/15603-0, 16/04591-1, 12/04831-1, 12/18724-2, 13/00713-7, 14/17251-9)

PINTO, RAPHAEL S.; MINANNI, CARLOS A.; DE ARAUJO LIRA, AECIO LOPES; PASSARELLI, MARISA. Advanced Glycation End Products: A Sweet Flavor That Embitters Cardiovascular Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 5, p. 17-pg., 2022-03-01. (18/00172-0, 16/15603-0)

MACHADO, U. F.. Atorvastatin improves glucose metabolism and reverses the diabetic state in a non-genetic mouse model of type 2 diabetes. Diabetologia, v. 66, n. SUPPL 1, p. 1-pg., 2023-09-01. (18/26013-5, 16/15603-0)

MICHALANI, MARIA LUIZA ESTIMO; PASSARELLI, MARISA; MACHADO, UBIRATAN FABRES. Nuclear Factor-Kappa-B Mediates the Advanced Glycation End Product-Induced Repression of Slc2a4 Gene Expression in 3T3-L1 Adipocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 15, p. 14-pg., 2024-08-01. (16/17002-4, 16/15603-0)

DE FATIMA MELLO SANTANA, MONIQUE; SAWADA, MARIA ISABELA BLOISE ALVES CALDAS; SOUZA JUNIOR, DOUGLAS RICARDO; GIACAGLIA, MARCIA BENACCHIO; REIS, MOZANIA; XAVIER, JACIRA; CORREA-GIANNELLA, MARIA LUCIA; SORIANO, FRANCISCO GARCIA; GEBRIM, LUIZ HENRIQUE; RONSEIN, GRAZIELLA ELIZA; et al. Proteomic Profiling of HDL in Newly Diagnosed Breast Cancer Based on Tumor Molecular Classification and Clinical Stage of Disease. CELLS, v. 13, n. 16, p. 19-pg., 2024-08-01. (19/18431-4, 19/25702-4, 21/02401-9, 16/15603-0, 23/00995-4)

DEL BIANCO, VANESSA; FERREIRA, GUILHERME DA SILVA; BOCHI, ANA PAULA GARCIA; PINTO, PAULA RAMOS; RODRIGUES, LETICIA GOMES; FURUKAWA, LUZIA NAOKO SHINOHARA; OKAMOTO, MARISTELA MITIKO; ALMEIDA, JAINE ALVES; DA SILVEIRA, LIZANDRE KEREN RAMOS; SANTOS, ARITANIA SOUSA; et al. Aerobic Exercise Training Protects Against Insulin Resistance, Despite Low-Sodium Diet-Induced Increased Inflammation and Visceral Adiposity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 18, p. 24-pg., 2024-09-01. (16/15603-0)

GIACAGLIA, MARCIA BENACCHIO; FELIX, VITORIA PIRES; SANTANA, MONIQUE DE FATIMA MELLO; AMENDOLA, LEONARDO SZALOS; LERNER, PEROLA GOBERSTEIN; FERNANDES, SIBELLE D. ELIA; CAMACHO, CLEBER PINTO; PASSARELLI, MARISA. The Composition of the HDL Particle and Its Capacity to Remove Cellular Cholesterol Are Associated with a Reduced Risk of Developing Active Inflammatory Rheumatoid Arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 20, p. 16-pg., 2024-10-01. (16/15603-0, 21/02401-9)

PINTO, R. S.; MACHADO, U. F.; PASSARELLI, M.. Advanced glycation end products as biomarkers for cardiovascular disease: browning clarifying atherogenesis. BIOMARKERS IN MEDICINE, v. 14, n. 8, p. 4-pg., 2020-06-01. (16/15603-0, 18/00172-0)

FATIMA, LUCIANA A.; CAMPELLO, RAQUEL S.; BARRETO-ANDRADE, JOAO N.; PASSARELLI, MARISA; SANTOS, ROBERTA S.; CLEGG, DEBORAH J.; MACHADO, UBIRATAN F.. Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA. Molecular and Cellular Endocrinology, v. 498, DEC 1 2019. (16/15603-0, 12/24210-1)

PINTO, PAULA R.; DA SILVA, KAROLLINE S.; IBORRA, RODRIGO T.; OKUDA, LIGIA S.; GOMES-KJERULF, DIEGO; FERREIRA, GUILHERME S.; MACHADO-LIMA, ADRIANA; ROCCO, DEBORA D. F. M.; NAKANDAKARE, EDNA R.; MACHADO, UBIRATAN F.; et al. Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice. FRONTIERS IN PHYSIOLOGY, v. 9, MAY 8 2018. (12/19112-0, 16/15603-0, 13/11084-0, 12/12088-7, 11/15153-1, 12/18724-2, 13/02854-7, 14/07617-6, 15/21072-5)

PINTO-JUNIOR, DANILO C.; SILVA, KAROLLINE S.; MICHALANI, MARIA L.; YONAMINE, CAIO Y.; ESTEVES, JOAO V.; FABRE, NELLY T.; THIEME, KARINA; CATANOZI, SERGIO; OKAMOTO, MARISTELA M.; SERAPHIM, PATRICIA M.; et al. Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression. SCIENTIFIC REPORTS, v. 8, MAY 25 2018. (12/20432-0, 16/15603-0, 16/25155-5, 12/18724-2, 13/00713-7, 14/17251-9)

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