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Biological evaluation and physicochemical properties of the surface of Titanium-15Mo submitted to hydrothermal treatment with strontium. in vitro study

Grant number: 18/09256-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2018
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Joni Augusto Cirelli
Grantee:Flavia Gomes Matos
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):19/10463-4 - Physicochemical characterization and biological analyses of two different methods for functionalization of Ti-15Mo alloy surface with strontium, BE.EP.MS


Surface treatments, development of new alloys and functionalization of the surfaces of implants with bioactive elements have been objectives of recent studies in the area of Dentistry aiming to contribute to the osseointegration process. The purpose of this study is to evaluate the physicochemical and biological characteristics of 15 molybdenum titanium disks subjected to the chemical-hydrothermal treatment with strontium in comparison to disks with smooth surfaces and with chemical treatment without the functionalization with strontium. The studied surfaces will be evaluated for topography and chemical composition by scanning electron microscopy tests associated to X-ray dispersive energy spectroscopy, X-ray diffraction, roughness measurements and effective area with laser confocal microscope, contact angle and electrochemical tests for corrosion evaluation. In addition, the response of pre-osteoblastic MC3T3-E1 cells to these surfaces will be evaluated by observing cell morphology, adhesion, proliferation and cytotoxicity, gene and protein expression of osteogenesis markers and evaluation of mineralization nodules. These results are expected to determine benefits and possible applications of this new surface treatment in Implantology.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATOS, FLAVIA GOMES; LEAL SANTANA, LUIS CARLOS; COMINOTTE, MARIANA ALINE; DA SILVA, FERNANDO SANTOS; VAZ, LUIS GERALDO; DE OLIVEIRA, DIEGO PEDREIRA; CIRELLI, JONI AUGUSTO. Strontium-loaded titanium-15molybdenum surface improves physicochemical and biological properties in vitro. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 8, n. 4, p. 16-pg., . (18/09256-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MATOS, Flavia Gomes. Evaluation of titanium-15 molybdenum surfaces submitted to strontium functionalization: in vitro analysis of physical-chemical and biological properties. 2020. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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