Evaluation of titanium-15 molybdenum surfaces submitted to strontium functionalization: in vitro analysis of physical-chemical and biological properties

Author(s)

Flávia Gomes Matos

• Document type: Master's Dissertation
• Press: Araraquara. 2020-04-16.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara
• Defense date: 2020-03-02
• Advisor: Joni Augusto Cirelli

Abstract

Surface treatments, development of new alloys and functionalization of implant surfaces with bioactive elements have been the objectives of recent studies in the field of Dentistry aimed at contributing to the process of osseointegration. In this dissertation, two studies investigated the influence on the in vitro cellular response and physical-chemical properties of Ti-15Mo alloys submitted to (1) strontium functionalization by the hydrothermal method previously submitted or not to chemical treatment with acid (H3PO4) and alkali (NaOH) and (2) two methods of strontium application: hydrothermal method and magnetron co-sputtering method. Tests of chemical composition and topography demonstrated that both techniques were effective in the application of strontium. In (1) the hydrothermal method reconciled the previous treatment with acid and alkali presented results of greater strontium quantification with slower release and better results in the analysis of wettability, surface energy and corrosion resistance. The biological tests verified that in (1) preosteoblastic cells MC3T3-E1 presented morphological characteristics of greater spreading and proliferation on surfaces with strontium addition. In (2) human periodontal ligament cells the results showed greater proliferation and spreading on surfaces treated by the magnetron co-sputtering method. The studies demonstrated that the addition of strontium contributed to cellular events and, combined with chemical treatment prior to the addition of strontium, promoted improvements in the physical-chemical properties of Ti-15Mo surfaces. In addition, the methods of application and chemical form of strontium were shown to influence initial cell responses. Analyses on the influence of in vivo treatments are necessary. (AU)

• FAPESP's process: 18/09256-1 - Biological evaluation and physicochemical properties of the surface of Titanium-15Mo submitted to hydrothermal treatment with strontium. in vitro study
• Grantee: Flavia Gomes Matos
• Support Opportunities: Scholarships in Brazil - Master