Prospecting for anticancer secondary metabolites produced by phytopathogenic fungi

• Grant number: 18/03670-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2018
• End date: August 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: João Ernesto de Carvalho
• Grantee: Jaqueline Moraes Bazioli
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

In the last three decades, microorganisms have been studied as a promising source of bioactive molecules with wide possibilities of use in the pharmaceutical industry in the treatment of various diseases. In this work, different phytopathogenic fungi will be studied in relation to the production of bioactive secondary metabolites, being 4 strains of the genus Penicillium. All strains will be cultured on a small scale and their extracts tested for their anticancer activities against a panel of ten human cancer cell lines: UACC-62 (Skin), MCF-7 (Human breast), NCI-ADR/RES (Ovary), 786- , NCI-H460 (Lung), PC-3 (Prostate), OVCAR-3 (Ovary), HT-29 (Colon-human), K562 (Bone marrow), U251 (CNS) and HaCat. Potential active extracts will be submitted to fractions and characterization of natural products with anti-tumor activity.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, EDER DE VILHENA; VENDRAMINI, PEDRO HENRIQUE; COSTA, JONAS HENRIQUE; EBERLIN, MARCOS NOGUEIRA; MONTAGNER, CASSIANA CAROLINA; FILL, TAICIA PACHECO. Determination of tryptoquialanines A and C produced by Penicillium digitatum in oranges: Are we safe?. Food Chemistry, v. 301, DEC 15 2019. (18/03670-0, 15/10384-6, 17/24462-4)

DE ANDRADE ALMEIDA, ALLAN CALMONT; DE MORAES PONTES, JOAO GUILHERME; ALVARENGA, GABRIEL RODRIGUES; FINOCCHIO, HENRIQUE; FILL, TAICIA PACHECO. The sustainable cycle of a new cacao-based bioplastic: from manufacturing to exploitable biodegradation products. RSC ADVANCES, v. 11, n. 48, p. 29976-29985, SEP 8 2021. (18/20930-6, 19/06359-7, 17/24462-4, 18/03670-0)

COSTA, JONAS HENRIQUE; BAZIOLI, JAQUELINE MORAES; DE MORAES PONTES, JOAO GUILHERME; FILL, TAICIA PACHECO. Penicillium digitatum infection mechanisms in citrus: What do we know so far?. FUNGAL BIOLOGY, v. 123, n. 8, p. 584-593, AUG 2019. (17/24462-4, 18/03670-0)

COSTA, JONAS HENRIQUE; BAZIOLI, JAQUELINE MORAES; ARAUJO, EDER DE VILHENA; VENDRAMINI, PEDRO HENRIQUE; DE FREITAS PORTO, MARIANA CRISTINA C.; EBERLIN, MARCOS NOGUEIRA; SOUZA-NETO, JAYME A.; FILL, TAICIA PACHECO. Monitoring indole alkaloid production by Penicillium digitatum during infection process in citrus by Mass Spectrometry Imaging and molecular networking. FUNGAL BIOLOGY, v. 123, n. 8, p. 594-600, AUG 2019. (13/11343-6, 17/24462-4, 18/03670-0)

MORAES BAZIOLI, JAQUELINE; BELINATO, JOAO RAUL; COSTA, JONAS HENRIQUE; AKIYAMA, DANIEL YURI; DE MORAES PONTES, JOAO GUILHERME; KUPPER, KATIA CRISTINA; AUGUSTO, FABIO; DE CARVALHO, JOAO ERNESTO; FILL, TAICIA PACHECO. Biological Control of Citrus Postharvest Phytopathogens. TOXINS, v. 11, n. 8, AUG 2019. (18/03670-0, 16/20547-2, 17/24462-4, 18/13027-8)

JOÃO RAUL BELINATO; JAQUELINE MORAES BAZIOLI; ALESSANDRA SUSSULINI; FABIO AUGUSTO; TAÍCIA PACHECO FILL. METABOLÔMICA MICROBIANA: INOVAÇÕES E APLICAÇÕES. Química Nova, v. 42, n. 5, p. 546-559, 2019-07-18. (16/20547-2, 18/03670-0, 17/24462-4)

DE MORAES PONTES, JOAO GUILHERME; VENDRAMINI, PEDRO HENRIQUE; FERNANDES, LAURA SOLER; DE SOUZA, FABRICIO HENRIQUE; PILAU, EDUARDO JORGE; EBERLIN, MARCOS NOGUEIRA; MAGNANI, RODRIGO FACCHINI; WULFF, NELSON ARNO; FILL, TAICIA PACHECO. Mass spectrometry imaging as a potential technique for diagnostic of Huanglongbing disease using fast and simple sample preparation. SCIENTIFIC REPORTS, v. 10, n. 1, AUG 10 2020. (19/06359-7, 17/24462-4, 18/03670-0)