Synthesis and photocrosslinking of unsaturated polyesters derived from isosorbide and panthenol for 3D printing of resorbable medical devices

• Grant number: 18/12602-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2018
• End date: February 29, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Henrique Catalani
• Grantee: Isabela Lima Autran Dourado
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 22/09992-5 - Light-based 3D printing techniques applied to panthenol-derived polymers, BE.EP.DD

Abstract

Tissue Engineering has been developed with remarkable success over the last years through the continuous development of new biomaterials. 3D printing, in turn, has been progressively enhanced since it allows the production of new accurate scaffolds; nevertheless, the medical field requires, increasingly, very specific properties for these materials. In this context, the goal of this project is to synthesize photocrosslinkable unsaturated polyesters that can be used as unprecedented biomaterials for 3D printing of resorbable medical devices. Syntheses will be investigated in (i) linear system, made by copolymers produced from pairs of diester/diol, in which diols are isosorbide and panthenol and unsaturated diesters are those synthesized from fumaric, glutaconic and trans-hydromuconic acids - these copolymers must also have the saturated diester derived from adipic acid; and (ii) globular system, in this case, made by hyperbranched structures based on these diols and tricarboxylic acids, like citric acid, followed by functionalization of these materials, using acrylic derivatives. The unsaturation inserted in both cases requires studying photocrosslinking of these copolymers and mechanical properties of films obtained to demonstrate the feasibility of using such polyesters as new resins for 3D printing. To make this possible, the photocrosslinkable polymer must have characteristics like: low molecular weight, low viscosity, biocompatibility and biodegradability. (AU)