Improvement of anthelmintic activity of ivermectin associated with essential oils

• Grant number: 18/18083-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2018
• End date: October 31, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Luciana Morita Katiki
• Grantee: Bruna Costa Rodrigues Wedy
• Host Institution: Instituto de Zootecnia. Agência Paulista de Tecnologia dos Agronegócios (APTA). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). Nova Odessa , SP, Brazil

Abstract

The global context reveals that the indiscriminate use of macrocyclic lactones, such as ivermectin, in the control of endoparasites in small ruminants, has selected a resistant and pathogenic gastrointestinal nematode of sheep, Haemonchus contortus. It is expected an improvement in the pharmacological characteristics of these drug, by the association of essential oils with the possibility of decreasing the activity of resistance mechanism. The objective of this work will be to evaluate the anthelmintic activity of ivermectin combined with essential oils under H. contortus of multiresistant strain to determine the activity given by CL50. The following oils will be evaluated: cinnamaldehyde, anethole, carvone, carvacrol and thymol mixed with ivermectin to increase the action. The most effective anthelmintic activity will be determined by the lower CL50 found.