Aqueous two-phase micellar systems based on ionic liquids as platforms for the curcumin encapsulation in polymeric micelles

• Grant number: 18/05111-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2018
• End date: December 31, 2019
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Jorge Pereira
• Grantee: Isabelle Souza Kurnik
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 19/05624-9 - Encapsulation and in vitro release studies of curcumin in polymeric micelles composed of PEO-PPO-PEO triblock copolymers, BE.EP.IC

Abstract

Polymer micelles (MP) are described as excellent carriers of drugs with low solubility in theaqueous environment, such as curcumin (CCM), an important antitumoral, but despite this,these nanostructures are mostly obtained from methods that use considerable fractions oforganic solvents. Thus, considering the concerns related to the high toxicity and flammability,denaturing effect and the solvents' disposal requirements, it is of utmost importance in thenanobiotechnological field to develop an innovative and alternative aqueous formulation fordelivering lipophilic drugs with poor water solubility. Accordingly, we believe that aqueoustwo-phase micellar systems (ATPMS) can be implemented as a new platform for obtainingMP using a more biocompatible process (i.e., without adding solvents), fast and efficient forCCM encapsulation. To achieve this objective, the present project aims to determine thebinodal curves for systems containing the copolymer Pluronic L35 in phosphate buffer (pH7.4) in the absence and presence of ionic liquids (ILs) as adjuvants. In addition, a secondstep will evaluate the ability of Pluronic L35/phosphate buffer + ILs in CCM encapsulation,using different temperatures and concentrations of L35, determining the rates ofencapsulation and loading the drug in the MP. Finally, it is intended to characterize thenanostructures and to study the stability and the in vitro release profile of CCM from themicellar aggregates at different temperatures and over time.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

KURNIK, ISABELLE S.; NORONHA, MARIANA A.; CAMARA, MAYRA C. C.; MAZZOLA, PRISCILA G.; VICENTE, ANTONIO A.; PEREIRA, JORGE F. B.; LOPES, ANDRE M.. Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids. Separation and Purification Technology, v. 250, NOV 1 2020. (14/16424-7, 17/10789-1, 19/05624-9, 18/05111-9, 19/08549-8, 18/10799-0)

KURNIK, ISABELLE S.; MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; LOPES, ANDRE M.. Amphiphilic copolymer aqueous solutions with cholinium ionic liquids as adjuvants: New insights into determination of binodal curves and phase-separation mechanisms. JOURNAL OF MOLECULAR LIQUIDS, v. 318, NOV 15 2020. (14/16424-7, 18/05111-9, 19/05624-9, 17/10789-1, 18/10799-0, 19/08549-8)

KURNIK, ISABELLE S.; D'ANGELO, NATALIA A.; MAZZOLA, PRISCILA G.; CHORILLI, MARLUS; KAMEI, DANIEL T.; PEREIRA, JORGE F. B.; VICENTE, ANTONIO A.; LOPES, ANDRE M.. Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules. BIOMATERIALS SCIENCE, v. 9, n. 6, p. 2183-2196, MAR 21 2021. (18/10799-0, 20/03727-2, 14/16424-7, 18/05111-9, 19/05624-9, 17/10789-1, 19/08549-8)