Encapsulation and in vitro release studies of curcumin in polymeric micelles composed of PEO-PPO-PEO triblock copolymers

• Grant number: 19/05624-9
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: June 15, 2019
• End date: October 14, 2019
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Jorge Pereira
• Grantee: Isabelle Souza Kurnik
• Supervisor: Antonio Augusto Vicente
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Universidade do Minho (UMinho), Portugal
• Associated to the scholarship: 18/05111-9 - Aqueous two-phase micellar systems based on ionic liquids as platforms for the curcumin encapsulation in polymeric micelles, BP.IC

Abstract

Curcumin (CCM) is a natural polyphenolic compound with antioxidant, antimicrobial and antitumor properties, but its hydrophobicity limits its therapeutic application. Nanotechnology can provide an effective method for improving aqueous solubility of this important drug. In such respects, polymeric micelles (MPs), self-assembly formed nanostructures from amphiphilic surfactants or copolymers, can thus provide a favorable environment in order to conduct the CCM in aqueous environment. Such an approach is of paramount importance in the clinical therapeutic field as well as in the nanotechnological field in order to develop an innovative and alternative formulation for delivering lipophilic drugs with low solubility in the aqueous environment. In order to achieve this objective, the present project intends to obtain MP formulations composed of Pluronic L35 for the encapsulation of CCM, using different proportions of CCM and Pluronic L35, and to estimate the encapsulation and loading rates of CCM in the obtained formulations. In addition, it is intended to characterize the MP formulations and to study their stability in terms of size, polydispersity index (PDI) and zeta potential (¶) by dynamic light scattering (DLS) and the in vitro release profile of MPCs at different temperatures over time. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KURNIK, ISABELLE S.; MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; LOPES, ANDRE M.. Amphiphilic copolymer aqueous solutions with cholinium ionic liquids as adjuvants: New insights into determination of binodal curves and phase-separation mechanisms. JOURNAL OF MOLECULAR LIQUIDS, v. 318, NOV 15 2020. (14/16424-7, 18/05111-9, 19/05624-9, 17/10789-1, 18/10799-0, 19/08549-8)

KURNIK, ISABELLE S.; NORONHA, MARIANA A.; CAMARA, MAYRA C. C.; MAZZOLA, PRISCILA G.; VICENTE, ANTONIO A.; PEREIRA, JORGE F. B.; LOPES, ANDRE M.. Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids. Separation and Purification Technology, v. 250, NOV 1 2020. (14/16424-7, 17/10789-1, 19/05624-9, 18/05111-9, 19/08549-8, 18/10799-0)

KURNIK, ISABELLE S.; D'ANGELO, NATALIA A.; MAZZOLA, PRISCILA G.; CHORILLI, MARLUS; KAMEI, DANIEL T.; PEREIRA, JORGE F. B.; VICENTE, ANTONIO A.; LOPES, ANDRE M.. Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules. BIOMATERIALS SCIENCE, v. 9, n. 6, p. 2183-2196, MAR 21 2021. (18/10799-0, 20/03727-2, 14/16424-7, 18/05111-9, 19/05624-9, 17/10789-1, 19/08549-8)