Polymer micelles (MP) are described as excellent carriers of drugs with low solubility in the aqueous environment, such as curcumin (CCM), an important antitumoral, but despite this, these nanostructures are mostly obtained from methods that use considerable fractions of organic solvents. Thus, considering the concerns related to the high toxicity and flammability, denaturing effect and the solvents' disposal requirements, it is of utmost importance in the nanobiotechnological field to develop an innovative and alternative aqueous formulation for delivering lipophilic drugs with poor water solubility. Accordingly, we believe that aqueous two-phase micellar systems (ATPMS) can be implemented as a new platform for obtaining MP using a more biocompatible process (i.e., without adding solvents), fast and efficient forCCM encapsulation. To achieve this objective, the present project aims to determine the binodal curves for systems containing the copolymer Pluronic L35 in phosphate buffer (pH7.4) in the absence and presence of ionic liquids (ILs) as adjuvants. In addition, a second step will evaluate the ability of Pluronic L35/phosphate buffer + ILs in CCM encapsulation, using different temperatures and concentrations of L35, determining the rates of encapsulation and loading the drug in the MP. Finally, it is intended to characterize the nanostructures and to study the stability and the in vitro release profile of CCM from the micellar aggregates at different temperatures and over time.
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