Study of causes of mortality among the different forms of dementia in data series from community sample submitted to autopsy and anatomic pathological analysis

• Grant number: 18/16626-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2018
• End date: October 31, 2019
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Paula Villela Nunes
• Grantee: Beatriz Astolfi Neves
• Host Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil

Abstract

Dementia is a progressive degenerative disease with high mortality, which causes prejudice in cognitive functions and usually affects the population of the elderly. Its etiology is multifactorial and still needs to be better elucidated. There are several studies about causes of mortality in patients with dementia, however, there are few about mortality among the different types of dementia. The objective of this study is to compare the causes of mortality based on the death certificate of individuals with (post-mortem) anatomopathological diagnose of Alzheimer's disease, vascular dementia, and dementia with Lewy bodies. This study will be done with individuals 50 years old or more and that were submitted to the autopsy.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NASLAVSKY, MICHEL SATYA; SUEMOTO, CLAUDIA K.; BRITO, LUCIANO ABREU; SCLIAR, MARILIA OLIVEIRA; FERRETTI-REBUSTINI, RENATA ELOAH; RODRIGUEZ, ROBERTA DIEHL; LEITE, RENATA E. P.; ARAUJO, NATHALIA MATTA; BORDA, VICTOR; TARAZONA-SANTOS, EDUARDO; et al. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. MOLECULAR PSYCHIATRY, v. 27, n. 11, p. 9-pg., 2022-09-07. (16/24326-0, 13/08028-1, 06/55318-1, 18/16626-0, 14/50931-3, 09/09134-4)

NICOLE REZENDE DA COSTA; LIVIA MANCINE; ROGERIO SALVINI; JULIANA DE MELO TEIXEIRA; ROBERTA DIEHL RODRIGUEZ; RENATA ELAINE PARAIZO LEITE; CAMILA NASCIMENTO; CARLOS AUGUSTO PASQUALUCCI; RICARDO NITRINI; WILSON JACOB-FILHO; et al. Microcephaly measurement in adults and its association with clinical variables. Revista de Saúde Pública, v. 56, 2022-05-27. (16/24326-0, 18/16626-0, 17/07089-8)

NUNES, PAULA VILLELA; SUEMOTO, CLAUDIA KIMIE; RODRIGUEZ, ROBERTA DIEHL; LEITE, RENATA ELAINE PARAIZO; NASCIMENTO, CAMILA; PASQUALUCCI, CARLOS AUGUSTO; NITRINI, RICARDO; JACOB-FILHO, WILSON; GRINBERG, LEA T.; LAFER, BENY. Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals. NEUROBIOLOGY OF AGING, v. 117, p. 10-pg., 2022-06-13. (16/24326-0, 17/07089-8, 18/16626-0)