Development of semi-solids systems in situ film forming containing anesthetics for treatment of herpes simplex

• Grant number: 18/07995-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2018
• End date: November 30, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Osvaldo de Freitas
• Grantee: Ana Clara Wada de Carvalho
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Infections by herpes simplex viruses are a problem in health public system in the whole world. Infections by simplex viruses type I are asymptomatic, remaining in latency and can be reactivated in specific conditions. The standard treatment is antiviral drugs but receives are common. The topical anesthetics offer pain relief, anti-inflammatory, and antiviral activity. The aim of this study is the development of polymeric compositions with prilocaine and lidocaine in hydrochloride forms, in an associate or not, for herpes treatment. The composition will be characterized with liberation and permeation profile and the drugs will be performed by HPLC. The rheological analysis will be done as well as bioadhesives properties. Statistics analysis will be done.