Evolution of HLA genes: population differentiation and signatures of recent select...
| Grant number: | 18/01371-6 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | January 01, 2019 |
| Effective date (End): | February 28, 2021 |
| Field of knowledge: | Biological Sciences - Genetics - Human and Medical Genetics |
| Principal Investigator: | Tábita Hünemeier |
| Grantee: | Marcos Araújo Castro e Silva |
| Home Institution: | Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 15/26875-9 - Native American genome diversity, AP.JP |
Abstract The admixture of three continental ancestry components, European, African and Native American, has shaped the Brazilian population. Historical record suggests that the slaves came from different regions of Africa (e.g. Angola, Congo, Mozambique), but the way these groups dispersed and admixed with native americans and europeans after arriving in Brazil are still poorly documented. In recent years, genetics ancestry analysis has become an important tool for unraveling the history and origin of populations. Here we will analyze 541 individuals from quilombo communities genotyped with Axiom Human Origins array (~600Kb SNPs). The present study aims to understand the formation and the dynamics of admixture in the quilombo communities, as well as to identify, through local ancestry analyzes, the Native American lineages present in the quilombola remnants genome. (AU) | |