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New perspective on sarcomeric adaptation at the miotendínea junction in experimental model of obesity associated with training training

Grant number: 18/20962-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): January 31, 2020
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal researcher:Adriano Polican Ciena
Grantee:Bruna Aléxia Cristofoletti Grillo
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil

Abstract

Obesity is characterized by excessive adiposity and is a extensive public health problem, which have influences in the development of cardiovascular diseases, vitamin deficiency, insulin resistance, mitochondrial dysfunction and promotes changes in muscle fiber phenotypes, which resultes in locomotor system adaptations. Skeletal striated muscle is fundamental for locomotion, composed of dynamic and contractile structures characterized by high plasticity, it also have functions an energy system that influences body metabolism. In internal region it is formed by microscopic structures, denominated sarcomeres it is a basic muscle contraction unit composed of protein myofilaments which together with muscle fibers and my tendinous junction (MTJ) are indispensable for locomotion. MTJ is a complex anatomical region that acts at the muscle-tendon interface, where transmits the contractile forces, and as muscle, it also undergoes adaptations to different stimuli, such exercise. Aerobic training refers to exercises involving large muscle groups in dynamic activities and reflects on positive changes in the body, such as contributing to it is oxidative metabolic capacities and offering protection against the development of several diseases. The objective of the present study is to verify that in the skeletal striated muscle, there are alterations in the JMT and in the sarcomere of the tibialis anterior and soleus muscles, in the experimental model of obesity and associated with treadmill training, besides new perspectives on sarcomerogenesis. Will be used 60 Wistar rats with 90 days, divided into (n=15): Sedentary Group (S), not submitted to any protocol, Trained Group (T), will be submitted to treadmill training protocol, Obesity Group (O), will be submitted to the hyperlipidic diet, and the Obesity / Trained Group (OT), submitted to hyperlipid diet and to treadmill training protocol. For analysis will be used the light microscopy methods with the technique of Hematoxylin-Eosin and Picro-Syrius, Myofibrillar ATPase and transmission electron microscopy for morphometric analysis.

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