Evaluation of the quimiopreventive potential of betulinic acid triterpene in rodents

• Grant number: 18/26595-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2019
• End date: November 30, 2019
• Field of knowledge: Biological Sciences - Genetics - Mutagenesis
• Principal Investigator: Denise Crispim Tavares Barbosa
• Grantee: Lucas Teixeira Souza de Oliveira
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Cancer is one of the major causes of death in the world, in this way colon cancer reach about 34.280 new incidents annually around the world. Currently there is an extensive variety of molecules, and natural bioactive compounds that aim to retard and prevent the cancer evolution, the triterpenes compose part of then. The triterpenes, such as betulinic acid (BA), has various biologic activity as anti-inflammatory, hepatoprotective, analgesic, anti-inflammatory, hepatoprotective, and analgesic, cardiotonic, sedative, bactericidal, fungicidal, antiviral, analgesic and antitumor. In especial, the BA showed chemopreventive effect against the genotoxicity induced per different mutagens in V79 cells. Thereby, this work aims to evaluate the chemopreventive potential of the triterpene BA in rodents. Therefore, will be investigate the potential antigenotoxic activity by means of micronucleus assay in peripheral blood of Swiss mouse and the anticarcinogenic potential using the aberrant crypt foci assay in colon of Wistar mice. The obtained results will contribute for the best understanding of this triterpene in human organism.