Effect of fluoride dentifrices containing hexametaphosphate on initial erosive lesions on enamel

• Grant number: 18/21082-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2019
• End date: February 29, 2020
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Alberto Carlos Botazzo Delbem
• Grantee: Alana Semenzin Rodrigues
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

In an erosive process, the dissolution pH of the products deposited on enamel by fluoride dentifrices is exceeded. The addition of sodium hexametaphosphate (HMP) has been shown to increase the ability of fluoridated dentifrices in caries processes in vitro. However, it was not determined whether dentifrices containing HMP would have an effect in the erosive process. Thus, the present in vitro study will evaluate the effect of fluoride dentifrice containing sodium hexametaphosphate on initial enamel erosion. Bovine enamel blocks (n=48) will be selected by initial surface hardness (SHi) and subjected to 4 experimental treatments (12 blocks/group): placebo (without F and without HMP), 1100 ppm F (1100), 1100 ppm F associated with 1% HMP (1100HMP) and 1% HMP (HMP). The blocks will be immersed in dentifrice suspension only once. Next, 4 erosive challenges (citric acid, 0.75%, pH 3.5, 1 minute, under agitation) will be performed. Final surface hardness measurements (SHf) will be performed after each challenge, to calculate the percentage of surface hardness change (%SHC). For analysis of the data the dentifrices and the time of exposure to the acid will be considered as factors of variation. The %SHC variable at each time will be submitted to analysis of variance of repeated measurements at two criteria followed by Student-Newman-Keuls test (p<0.05).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES DE TOLEDO, PRISCILA TONINATTO; BOTAZZO DELBEM, ALBERTO CARLOS; CANNON, MARK LLOYD; SAKAMOTO, AMANDA ELIANE; PEDRINI, DENISE. The effect of toothpaste with reduced concentration of fluoride-containing sodium trimetaphosphate and polyols on initial enamel erosion. CLINICAL ORAL INVESTIGATIONS, v. 26, n. 12, p. 10-pg., 2022-08-19. (18/21082-9)