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Mediator role of physical activity and C-reactive protein in the relationship between obesity and arterial thickening in adolescents: ABCD growth study

Grant number: 18/09131-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2019
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Rômulo Araújo Fernandes
Grantee:Wésley Torres
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Objective: Analyze the relationship between body fat and arterial thickening among adolescents, as well as to identify the possible mediating role of physical activity and C-reactive protein in this process. Methods: Cross-sectional study, with data from the longitudinal study "Analysis of Behaviors of Children During Growth" (ABCD Growth Study) developed in the city of Presidente Prudente, SP. The sample will be composed of adolescents aged between 11 and 17 years, previously estimated sample size, dichotomized in sporting (adolescents involved in sports practices recruited from sports clubs and gymnasiums) and non-sports (school children who do not participate in organized sports). Adolescents will be included according to the following inclusion criteria: i) age between 11 and 17 years; (ii) does not have a metabolic and / or clinical disorder (previously diagnosed) that disrupts the practice of habitual physical activity; (iii) not make use of medicine that may interfere with blood pressure; iv) minimum involvement of 12 months in the sporting modality; v) the consent and consent signed by parents and volunteers, respectively; iv). non-sport group, in the last 12 months, not to be involved in sports activities. Study variables: Body fat will be estimated by bone densitometry. Carotid (CIMT) and femoral intima-media thickness (FIMT) arteries will be evaluated using an ultrasound device (Figlabs brand, model FP 102, Brazil). Physical activity will be estimated using an accelerometer (POLAR®, model V800 - Kempele, Finlândia), and C-reactive protein (CRP) will be dosed through a specific kit. Body weight and height will be measured in order to estimate the peak high velocity. Total cholesterol and fractions (HDL-c, LDL-c) and triglycerides will be measured in order to make up the dyslipidemia. Systolic and diastolic blood pressure will be measured by an automatic device. Numerical variables will be presented mean, standard deviation and confidence interval of 95%, Student's t-test for independent samples will be used in order to compare numerical variables according to sex and physical activity practice. Pearson's correlation will be used to verify the relationship between obesity and arterial thickening. Structural equation model will be used to evaluate the relationship between obesity and arterial thickness taking into account the mediating role of physical activity and C reactive protein, adjusted for sex, chronological age, blood pressure, biological maturation and dyslipidemia. All analyzes will be performed in the following software BioEstat (version 5.0) and Stata (version 15.0), statistical significance p <0.05. Expected Results: It is expected to identify whether obesity affects arterial thickening, as well as whether physical activity and inflammation may mediate this process. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TORRES, WESLEY; CAYRES-SANTOS, SUZIANE UNGARI; URBAN, JACQUELINE BEXIGA; DE MORAES-CHAGAS, LUCAS GABRIEL; CHRISTOFARO, DIEGO GIULLIANO DESTRO; TURI-LYNCH, BRUNA CAMILO; CODOGNO, JAMILE SANCHES; FERNANDES, ROMULO ARAUJO. Participation in Non-professional Sports and Cardiovascular Outcomes Among Adolescents: ABCD Growth Study. MATERNAL AND CHILD HEALTH JOURNAL, v. 24, n. 6 APR 2020. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TORRES, Wésley. Papel mediador da atividade física e proteína c reativa na relação entre obesidade e espessamento arterial em adolescentes : ABCD growth study. 2020. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências e Tecnologia..

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