Ultra-processed food consumption and incidence of diabetes in the English population: Biobank cohort

• Grant number: 18/26660-0
• Support Opportunities: Scholarships abroad - Research
• Effective date (Start): June 01, 2019
• Effective date (End): July 31, 2019
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Renata Bertazzi Levy
• Grantee: Renata Bertazzi Levy
• Host Investigator: Christopher Millett
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Research place: Imperial College London, England
• Associated research grant: 15/14900-9 - Consumption of ultra-processed foods, dietary nutrient profile diet and obesity in seven countries, AP.TEM

Abstract

In recent years the prevalence of obesity and diabetes have reached alarming rates. This situation may be related to the worldwide increase in the dietary share of ultraprocessed foods. The aim of this proposal is to advance in the analysis of the influence of ultraprocessed foods consumption on health outcomes, particularly obesity and diabetes and increase the robustness of the causal relationship. A prospective study of the association between consumption of ultra-processed foods and the incidence of diabetes, mediated by obesity in the UK population will be carried out. We will use data from the Biobank cohort, which has been following the UK adult population since 2006. Our exposure variable will be the share of ultraprocessed foods in total calories and our outcomes, the incidence of diabetes, mediated by obesity. Measures of proportional hazards will be obtained using Cox regression models. Mediation analyses will be conducted to explore and quantify the total direct and indirect effects of obesity in these associations. Additionally, we intend to strengthen the institutional partnership between the University of São Paulo and the Imperial College of London, and provide knowledge of longitudinal study analysis techniques, enabling the creation of a postgraduate course in Preventive Medicine in Brazil. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAUBER, FERNANDA; CHANG, KIARA; VAMOS, ESZTER P.; DA COSTA LOUZADA, MARIA LAURA; MONTEIRO, CARLOS AUGUSTO; MILLETT, CHRISTOPHER; LEVY, RENATA BERTAZZI. Ultra-processed food consumption and risk of obesity: a prospective cohort study of UK Biobank. EUROPEAN JOURNAL OF NUTRITION, v. 60, n. 4, p. 2169-2180, JUN 2021. (18/26660-0, 15/14900-9, 16/14302-7, 18/19820-1)

LEVY, RENATA B.; RAUBER, FERNANDA; CHANG, KIARA; LOUZADA, MARIA LAURA DA C.; MONTEIRO, CARLOS A.; MILLETT, CHRISTOPHER; VAMOS, ESZTER P.. Ultra-processed food consumption and type 2 diabetes incidence: A prospective cohort study. Clinical Nutrition, v. 40, n. 5, p. 3608-3614, MAY 2021. (18/19820-1, 16/14302-7, 18/26660-0, 15/14900-9)