Introduction: despite the vast number of medications currently available for the treatment of type 2 diabetes (DM2), and the many public guidelines on its management, a large number of patients remains with the disease uncontrolled. Some studies have shown that less than 10% of the affected individuals have controlled the disease according to the proposed recommendations. The most relevant risk factor regarding DM2 complications is an inadequate glycemic control. Objective: evaluate the effectiveness of strategies in primary health care that aim a greater engagement of patients on their treatment and DM2 control. Methods: we will perform a systematic review according to Cochrane collaboration, and a network meta-analysis with the MTC method (Mixed Treatment Comparisons). We will included randomized studies, in which patients with DM2 were allocated to strategies that increased their engagement in the treatment of their disease (intervention) or subjected to standard treatment (medical appointments and general recommendations on lifestyle changes) (control). The primary outcomes that will be analyzed are quality of life, the patient's satisfaction with the treatment, glycemic control and the control of hypertension and dyslipidemia, frequency of cardiac event and deaths. The secondary outcomes analyzed will be: weight loss (evaluate through final weight or waist circumference or body mass index (BMI), number of patients in each group with HbA1c <6.5, number of patients in each group with HA1c <7, average difference of HbA1c between control and intervention at 3, 6, 12, 18 and 24 months. Change of the HbA1c from the first and last visitation, need of inpatient care due to acute or chronic complications of DM, and cost.
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